SIMPLEX OPTIMIZATION OF RESPONSE FROM CHEMICAL SYSTEMS

An experiment design based on the simplex configuration offers an efficient approach to determining which levels of the controlling variables (or factors) give the maximum response from a system. This paper presents details for applying simplex optimization to chemical problems. A design matrix is given for locating the vertices of the initial simplex for up to 10 factors and a form is included for calculating the new points. A graphical technique is described for tlie two-factor case. © 1969.