A THEORETICAL-STUDY ON THE METABOLIC-ACTIVATION OF PARACETAMOL BY CYTOCHROME-P-450 - INDICATIONS FOR A UNIFORM OXIDATION MECHANISM

被引：52

作者：

KOYMANS, L

VANLENTHE, JH

VANDESTRAAT, R

DENKELDER, GMDO

VERMEULEN, NPE

机构：

[1] FREE UNIV AMSTERDAM,DEPT PHARMACOCHEM MOLEC TOXICOL,DE BOELELAAN 1083,1081 HV AMSTERDAM,NETHERLANDS

[2] STATE UNIV UTRECHT,DEPT THEORET CHEM,3584 CS UTRECHT,NETHERLANDS

来源：

CHEMICAL RESEARCH IN TOXICOLOGY | 1989年 / 2卷 / 01期

关键词：

D O I：

10.1021/tx00007a011

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

引用

页码：60 / 66

页数：7

共 42 条

[1]

ALBANO E, 1985, MOL PHARMACOL, V28, P306

[2] LIVER NECROSIS FROM PARACETAMOL [J].

BOYD, EM ;

BERECZKY, GM .

BRITISH JOURNAL OF PHARMACOLOGY AND CHEMOTHERAPY, 1966, 26 (03) :606-&

[3] N-HYDROXYACETAMINOPHEN - A POSTULATED TOXIC METABOLITE OF ACETAMINOPHEN [J].

CALDER, IC ;

HART, SJ ;

HEALEY, K ;

HAM, KN .

JOURNAL OF MEDICINAL CHEMISTRY, 1981, 24 (08) :988-993

[4]

Clark T., 1985, HDB COMPUTATIONAL CH

[5] SELF-CONSISTENT MOLECULAR-ORBITAL METHODS .17. GEOMETRIES AND BINDING-ENERGIES OF 2ND-ROW MOLECULES - COMPARISON OF 3 BASIS SETS [J].

COLLINS, JB ;

SCHLEYER, PV ;

BINKLEY, JS ;

POPLE, JA .

JOURNAL OF CHEMICAL PHYSICS, 1976, 64 (12) :5142-5151

[6]

CORCORAN GB, 1980, MOL PHARMACOL, V18, P536

[7] N-ACETYL-PARA-BENZOQUINONE IMINE - A CYTOCHROME-P-450-MEDIATED OXIDATION-PRODUCT OF ACETAMINOPHEN [J].

DAHLIN, DC ;

MIWA, GT ;

LU, AYH ;

NELSON, SD .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA-BIOLOGICAL SCIENCES, 1984, 81 (05) :1327-1331

[8] DISSOCIATION OF CELL-DEATH FROM COVALENT BINDING OF PARACETAMOL BY FLAVONES IN A HEPATOCYTE SYSTEM [J].

DEVALIA, JL ;

OGILVIE, RC ;

MCLEAN, AEM .

BIOCHEMICAL PHARMACOLOGY, 1982, 31 (23) :3745-3749

[9] GROUND-STATES OF MOLECULES .38. MNDO METHOD - APPROXIMATIONS AND PARAMETERS [J].

DEWAR, MJS ;

THIEL, W .

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 1977, 99 (15) :4899-4907

[10]

Dupuis M., 1980, NRCC SOFTWARE CATALO, V1

← 1 2 3 4 5 →