FLOW CYTOMETRIC ANALYSIS IN COLORECTAL-CARCINOMA - PROGNOSTIC-SIGNIFICANCE OF CELLULAR DNA CONTENT

被引：22

作者：

SCHILLACI, A ^{[1
]}

TIRINDELLI, DD ^{[1
]}

FERRI, M ^{[1
]}

TEODORI, L ^{[1
]}

MAURO, F ^{[1
]}

NICOLANTI, V ^{[1
]}

STIPA, S ^{[1
]}

机构：

[1] UNIV ROME LA SAPIENZA,DEPT SURG,I-00185 ROME,ITALY

来源：

INTERNATIONAL JOURNAL OF COLORECTAL DISEASE | 1990年 / 5卷 / 04期

关键词：

D O I：

10.1007/BF00303281

中图分类号：

R57 [消化系及腹部疾病];

学科分类号：

摘要：

The prognostic value of DNA ploidy status was evaluated prospectively in 70 patients with colorectal carcinoma. Cellular DNA content was measured by flow cytometry from fresh specimens with multiple site sampling. Seventy-five percent of cases exhibited a DNA aneuploid pattern. In a univariate analysis, DNA ploidy status showed a statistically significant correlation with survival (p < 0.05), weaker than Dukes' stage (p < 0.001). No correlation was observed between survival and presence of multiple DNA stemlines. In a multivariate analysis, Dukes' stage was the strongest prognostic indicator (p = 0.01) while DNA ploidy status did not show an independent prognostic value. It is concluded that DNA ploidy status is associated with pathological features of aggressive malignancy, but it does not have a determinant role in predicting survival.

引用

页码：223 / 227

页数：5

共 12 条

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