IMMUNOSPECIFIC SUPPRESSION OF ENCEPHALITOGENIC-ACTIVATED LYMPHOCYTES-T BY CHIMERIC CYTOTOXIN IL-2-PE40

被引：15

作者：

BERAUD, E ^{[1
]}

LORBERBOUMGALSKI, H ^{[1
]}

CHAN, CC ^{[1
]}

FITZGERALD, D ^{[1
]}

PASTAN, I ^{[1
]}

NUSSENBLATT, RB ^{[1
]}

机构：

[1] NCI,MOLEC BIOL LAB,BETHESDA,MD 20892

来源：

CELLULAR IMMUNOLOGY | 1991年 / 133卷 / 02期

关键词：

D O I：

10.1016/0008-8749(91)90112-O

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

We examined the action of a chimeric protein, IL-2-PE40, on the development of a T cell-mediated disease of the central nervous system with numerous similarities to multiple sclerosis, experimental autoimmune encephalomyelitis (EAE). EAE is caused by IL-2 receptor-bearing T cells specific for myelin basic protein (BP). We report here that the treatment of Lewis rats with IL-2-PE40 delayed and shortened the course of EAE induced by BP in adjuvant and dramatically prevented EAE mediated by anti-myelin basic protein T line cells. The absence of paralytic signs, the absence of cell infiltration in the central nervous system, and the abatement of cellular immunity to myelin basic protein in the treated rats are direct consequences of the specific mechanism of action of IL-2-PE40. Our data support the notion that IL-2-PE40 may be efficient as an immunosuppressive agent for those disorders in which activated T cells play a crucial role. © 1991.

引用

页码：379 / 389

页数：11

共 49 条

[1] PURIFICATION AND PARTIAL CHARACTERIZATION OF AN INTERLEUKIN 2 PSEUDOMONAS EXOTOXIN FUSION PROTEIN [J].