CARBOALUMINATION OF 1-ALKYNES AND INSITU TRANSMETALATION TO HIGHER-ORDER CYANOCUPRATES - STEREOSPECIFIC SYNTHESIS OF TRISUBSTITUTED AND DISUBSTITUTED OLEFINS BY CONJUGATE ADDITION TO ENONES

A method is described for the direct carbo-alumination and in situ cuprate exchange that makes possible the conjugate addition of disubstituted (R, CH3) or monosubstituted (R, H) vinyl anions to α,β-unsaturated ketones. The process results in high yields (63-95%) of conjugate addition products without the customary intervention of the more standard vinyl iodide and then cuprate formation. © 1990, American Chemical Society. All rights reserved.