INCIDENCE OF GASTRIC-LESIONS IN PATIENTS WITH RHEUMATIC DISEASE ON CHRONIC ASPIRIN THERAPY

被引：370

作者：

SILVOSO, GR ^{[1
]}

IVEY, KJ ^{[1
]}

BUTT, JH ^{[1
]}

LOCKARD, OO ^{[1
]}

HOLT, SD ^{[1
]}

SISK, C ^{[1
]}

BASKIN, WN ^{[1
]}

MACKERCHER, PA ^{[1
]}

HEWETT, J ^{[1
]}

机构：

[1] UNIV MISSOURI, COLUMBIA, MO 65201 USA

来源：

ANNALS OF INTERNAL MEDICINE | 1979年 / 91卷 / 04期

关键词：

D O I：

10.7326/0003-4819-91-4-517

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Endoscopy was done in 82 patients with rheumatic disease who were receiving chronic aspirin therapy. Fifty-eight patients were taking at least eight aspirin tablets daily for 3 or more months; 24 patients were taking, in addition to the aspirin, a maximum of one other antiinflammatory, nonsteroidal medication. Endoscopy in 45 normal subjects not taking aspirin showed no ulcers or erosions and a 4% incidence of gastric erythema. In the 82 patients with rheumatic disease, 14 (17%) had gastric ulcers, 33 (40%) had gastric erosions, and 62 (76%) had gastric erythema. Regular aspirin and buffered aspirin users had an ulcer incidence of 23% and 31%, respectively, compared with a 6% incidence in enteric-coated aspirin users (P < 0.05). One third of all patients with gastric ulcer had no gastrointestinal symptoms. Patients taking chronic aspirin therapy for rheumatic diseases have a higher than suspected incidence of gastric ulcer and erosions. Gastric ulcer may exist without symptoms in such patients.

引用

页码：517 / 520

页数：4