NMR ANALYSIS OF FLUORINATED CORTICOSTEROIDS RELATED TO FLUOCINONIDE - DETECTION OF LONG-RANGE H-1 F-19 COUPLINGS USING THE HETERONUCLEAR EQUIVALENT OF THE COSY EXPERIMENT

被引：21

作者：

HUGHES, DW ^{[1
]}

BAIN, AD ^{[1
]}

ROBINSON, VJ ^{[1
]}

机构：

[1] SYNTEX LTD,MISSISSAUGA L5N 3X4,ONTARIO,CANADA

来源：

MAGNETIC RESONANCE IN CHEMISTRY | 1991年 / 29卷 / 04期

关键词：

H-1; NMR; F-19; CORTICOSTEROIDS; H-1 F-19 LONG-RANGE COUPLING; HETERONUCLEAR COSY; H-1 F-19 2D CORRELATION;

D O I：

10.1002/mrc.1260290417

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

The analysis of the H-1 and F-19 NMR spectra of the corticosteroid fluocinonide and five related steroids is reported. The 500 MHz H-1 NMR spectra revealed several previously undetected long-range H-1 - F-19 coupling constants. These couplings were assigned by the application of the heteronuclear equivalent of the COSY pulse sequence. The fluorine substituent effects and long-range heteronuclear couplings were examined in relation to structures derived from molecular mechanics (MMX) calculations.

引用

页码：387 / 397

页数：11

共 34 条

[1] HETERONUCLEAR CHEMICAL-SHIFT CORRELATION BY FULLY COUPLED PHASE-SENSITIVE TWO-DIMENSIONAL NMR, A ROBUST EXPERIMENT [J].