SPATIAL MEMORY IN AGED RATS - POPULATION HETEROGENEITY AND EFFECT OF LEVOCARNITINE ACETYL

被引：33

作者：

GHIRARDI, O ^{[1
]}

GIULIANI, A ^{[1
]}

CAPRIOLI, A ^{[1
]}

RAMACCI, MT ^{[1
]}

ANGELUCCI, L ^{[1
]}

机构：

[1] UNIV ROME LA SAPIENZA,FAC MED,INST PHARMACOL 2,I-00185 ROME,ITALY

来源：

JOURNAL OF NEUROSCIENCE RESEARCH | 1992年 / 31卷 / 02期

关键词：

AGING; CLUSTER ANALYSIS; MORRIS WATERMAZE;

D O I：

10.1002/jnr.490310220

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

The existence in a population of aging rats of classes that display a different performance in the Morris water-maze test was investigated by cluster analysis procedure. These classes identified at 18 months of age showed a different response to levocarnitine acetyl and had a different behavioral profile when tested at 25 months of age. These findings demonstrate the need for an alternative interpretation of variability in animal populations as measured by the standard statistical analyses. The data analysis strategy we propose here will allow for the use of variability as a useful source of information.

引用

页码：375 / 379

页数：5

共 33 条

[1]

ANGELUCCI L, 1986, CLIN NEUROPHARMACOL, V9, P104

[2] FORMAL DEFINITION OF ORGANIZATION [J].

ATLAN, H .

JOURNAL OF THEORETICAL BIOLOGY, 1974, 45 (02) :295-304

[3] AGING BRAIN - EFFECT OF ACETYL-L-CARNITINE TREATMENT ON RAT-BRAIN ENERGY AND PHOSPHOLIPID-METABOLISM - A STUDY BY P-31 AND H-1-NMR SPECTROSCOPY [J].

AURELI, T ;

MICCHELI, A ;

RICCIOLINI, R ;

DICOCCO, ME ;

RAMACCI, MT ;

ANGELUCCI, L ;

GHIRARDI, O ;

CONTI, F .

BRAIN RESEARCH, 1990, 526 (01) :108-112

[4] ACETYL-1-CARNITINE .2. EFFECTS ON LEARNING AND MEMORY PERFORMANCE OF AGED RATS IN SIMPLE AND COMPLEX MAZES [J].

BARNES, CA ;

MARKOWSKA, AL ;

INGRAM, DK ;

KAMETANI, H ;

SPANGLER, EL ;

LEMKEN, VJ ;

OLTON, DS .

NEUROBIOLOGY OF AGING, 1990, 11 (05) :499-506

[5] PROFOUND EFFECTS OF COMBINING CHOLINE AND PIRACETAM ON MEMORY ENHANCEMENT AND CHOLINERGIC FUNCTION IN AGED RATS [J].

BARTUS, RT ;

DEAN, RL ;

SHERMAN, KA ;

FRIEDMAN, E ;

BEER, B .

NEUROBIOLOGY OF AGING, 1981, 2 (02) :105-111

[6] CLUSTER-ANALYSIS OF SHORT-TERM TESTS - A NEW METHODOLOGICAL APPROACH [J].

BENIGNI, R ;

GIULIANI, A .

MUTATION RESEARCH, 1985, 147 (04) :139-151

[7]

BLISS CI, 1967, STATISTICS BIOL, V1

[8]

BLUM K, 1971, J PHARMACOL EXP THER, V178, P331

[9] AGE-DEPENDENT DEFICITS IN RADIAL MAZE PERFORMANCE IN THE RAT - EFFECT OF CHRONIC TREATMENT WITH ACETYL-L-CARNITINE [J].

CAPRIOLI, A ;

GHIRARDI, O ;

RAMACCI, MT ;

ANGELUCCI, L .

PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY, 1990, 14 (03) :359-369

[10]

CAPRIOLI A, 1991, IN PRESS NEUROBIOL A

← 1 2 3 4 →