THE A-ALPHA MATING LOCUS OF SCHIZOPHYLLUM-COMMUNE ENCODES 2 DISSIMILAR MULTIALLELIC HOMEODOMAIN PROTEINS

被引：100

作者：

STANKIS, MM

SPECHT, CA

YANG, HL

GIASSON, L

ULLRICH, RC

NOVOTNY, CP

机构：

[1] UNIV VERMONT, DEPT MICROBIOL & MOLEC GENET, BURLINGTON, VT 05405 USA

[2] UNIV VERMONT, DEPT BOT, BURLINGTON, VT 05405 USA

来源：

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA | 1992年 / 89卷 / 15期

关键词：

DEVELOPMENTAL GENES; FUNGI;

D O I：

10.1073/pnas.89.15.7169

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

The A-alpha-mating locus is one of four multiallelic loci that govern sexual development in the basidiomycete fungus Schizophyllum commune. We have determined the nucleotide sequence encoding three A-alpha-mating types, A-alpha-1, A-alpha-3, and A-alpha-4. We have found that the locus for A-alpha-3 and A-alpha-4 consists of two genes: Y and Z. The locus for A-alpha-1 encodes only one gene, Y. The Z polypeptides encoded by different alleles exhibit 42% identity. The Y polypeptides exhibit 49-54% identity. The finding that the deduced Z and Y polypeptides have homeodomain motifs suggests that these polypeptides may be DNA-binding regulatory proteins that control the expression of developmental genes. The deduced Z polypeptide also has acidic regions that might be functionally analogous to the acidic regions in yeast GAL4 and GCN4 that activate transcription. The Y polypeptide has a serine-rich region and a basic region that shows some identity to the lysine-rich region of H1 histones.

引用

页码：7169 / 7173

页数：5

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