Reversibility of the differentiated state in somatic cells

被引：25

作者：

Baron, Margaret H. ^{[1
]}

机构：

[1] Harvard Univ, Dept Cellular & Dev Biol, Cambridge, MA 02138 USA

来源：

CURRENT OPINION IN CELL BIOLOGY | 1993年 / 5卷 / 06期

基金：

美国国家卫生研究院;

关键词：

D O I：

10.1016/0955-0674(93)90091-4

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Analysis of de novo gene activation in multinucleated heterokaryons has shown that the differentiated state, although stable, is not irreversible, and can be reprogrammed in the presence of appropriate combinations of trans-acting regulatory molecules. These properties have been exploited to design strategies for identifying novel regulators of cellular differentiation.

引用

页码：1050 / 1056

页数：7

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