IS THE OSTEOPETROTIC (OP/OP MUTANT) MOUSE COMPLETELY DEFICIENT IN EXPRESSION OF MACROPHAGE-COLONY-STIMULATING FACTOR

被引：21

作者：

HUME, DA

FAVOT, P

机构：

[1] Centre for Molecular, Cellular Biology, University of Queensland

来源：

JOURNAL OF INTERFERON AND CYTOKINE RESEARCH | 1995年 / 15卷 / 04期

关键词：

D O I：

10.1089/jir.1995.15.279

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The op/op mouse has a mutation in the macrophage colony-stimulating (CSF-1) gene. The phenotype of gross deficiency in the macrophage and osteoclast lineages corrects significantly with age, suggesting that other factors can substitute for CSF-1. This review examines the evidence that the op/op mouse is completely CSF-1 deficient and considers the possibility that alternative splicing within the CSF-1 gene might bypass the mutation, yielding an incompletely penetrant phenotype.

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页码：279 / 284

页数：6

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