ANTIBODIES TO INTERLEUKIN-1 INHIBIT CYTOKINE-INDUCED PROLIFERATION OF NEONATAL RAT SCHWANN-CELLS INVITRO

被引：25

作者：

LISAK, RP

BEALMEAR, B

机构：

[1] Department of Neurology. Wayne State University School of Medicine, Detroit

来源：

JOURNAL OF NEUROIMMUNOLOGY | 1991年 / 31卷 / 02期

关键词：

SCHWANN CELL; CYTOKINE; INTERLEUKIN-1; INTERLEUKIN-2;

D O I：

10.1016/0165-5728(91)90018-3

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Unfractionated cytokines have been shown to induce in vitro proliferation of neonatal rat Schwann cells but the nature of the mitogen(s) is not known. A mixture of rabbit antibodies specific for recombinant interleukin-1-alpha (IL-1-alpha) and interleukin-1-beta (IL-1-beta) inhibited Schwann cell proliferation induced by unfractionated human cytokines whereas antibodies to interleukin-2 (IL-2) and control IgG did not. However, purified human IL-1 and recombinant human IL-1-alpha or beta did not induce Schwann cell proliferation on their own.

引用

收藏

页码：123 / 132

页数：10

相关论文

共 52 条

[1] CELLULAR UPTAKE OF EXOGENOUS HORSERADISH-PEROXIDASE IN MOUSE PERIPHERAL-NERVE [J].

ARVIDSON, B .

ACTA NEUROPATHOLOGICA, 1977, 37 (01) :35-41

[2] MACROPHAGE-MEDIATED MYELIN-RELATED MITOGENIC FACTOR FOR CULTURED SCHWANN-CELLS [J].

BAICHWAL, RR ;

BIGBEE, JW ;

DEVRIES, GH .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1988, 85 (05) :1701-1705

[3]

BEDEOVSKY H, 1987, J NEUROSCI, V18, P172

[4] STIMULATION OF OLIGODENDROGLIAL PROLIFERATION AND MATURATION BY INTERLEUKIN-2 [J].

BENVENISTE, EN ;

MERRILL, JE .

NATURE, 1986, 321 (6070) :610-613

[5] PURIFICATION AND CHARACTERIZATION OF A HUMAN LYMPHOCYTE-T-DERIVED GLIAL GROWTH-PROMOTING FACTOR [J].

BENVENISTE, EN ;

MERRILL, JE ;

KAUFMAN, SE ;

GOLDE, DW ;

GASSON, JC .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1985, 82 (11) :3930-3934

[6]

BEUCHE W, 1984, J NEUROCYTOL, V13, P767, DOI 10.1007/BF01148493

[7]

BROCKES JP, 1980, J BIOL CHEM, V255, P8374

[8] PLATELET-DERIVED GROWTH-FACTORS AND FIBROBLAST GROWTH-FACTORS ARE MITOGENS FOR RAT SCHWANN-CELLS [J].

DAVIS, JB ;

STROOBANT, P .

JOURNAL OF CELL BIOLOGY, 1990, 110 (04) :1353-1360

[9] AXOLEMMA-ENRICHED FRACTIONS-ISOLATED FROM PNS AND CNS ARE MITOGENIC FOR CULTURED SCHWANN-CELLS [J].

DEVRIES, GH ;

SALZER, JL ;

BUNGE, RP .

DEVELOPMENTAL BRAIN RESEARCH, 1982, 3 (02) :295-299

[10] MULTIPLE BIOLOGICAL-ACTIVITIES OF HUMAN RECOMBINANT INTERLEUKIN-1 [J].

DINARELLO, CA ;

CANNON, JG ;

MIER, JW ;

BERNHEIM, HA ;

LOPRESTE, G ;

LYNN, DL ;

LOVE, RN ;

WEBB, AC ;

AURON, PE ;

REUBEN, RC ;

RICH, A ;

WOLFF, SM ;

PUTNEY, SD .

JOURNAL OF CLINICAL INVESTIGATION, 1986, 77 (06) :1734-1739

← 1 2 3 4 5 6 →