JATROPHAM DERIVATIVES AND STEROIDAL SAPONINS FROM THE BULBS OF LILIUM-HANSONII

Two new jatropham derivatives and three new steroidal saponins were isolated from the fresh bulbs of Lilium hansonii, along with previously known compounds. The structures of the new compounds were elucidated, on the basis of spectroscopic data and chemical evidence, and by comparing them with those of known compounds, as (-)-5-hydroxy-3-methyl-3-pyrrolin-2-one (jatropham) 5-O-beta-D-glucopyranosyl-(1 --> 3)-beta-D-glucopyranoside, (2S*,4R*)-1-(3-methyl-2-oxo-3-pyrrolinyl)-4-methyl-5-oxo-2-pyrrolidinecarboxylic acid, 26-O-beta-D-glucopyranosyl-(25R)-5-alpha-furostan-3-beta,22-xi-diol 3-O-alpha-L-rhamnopyranosyl-(1 --> 2)-O-[beta-D-glucopyranosyl-(1 --> 4)]-beta-D-glucopyranoside, (25R)-5-alpha-spirostan-3-beta,12-alpha-diol 3-O-alpha-L-rhamnopyranosyl-(1 --> 2)-O-[beta-D-glucopyranosyl-(1 --> 4)]-beta-D-glucopyranoside and (25R)-spirost-5-en-3-beta,12-alpha-diol 3-O-alpha-L-rhamnopyranosyl-(1 --> 2)-O-[beta-D-glucopyranosyl-(1 --> 4)]-beta-D-glucopyranoside, respectively. The stereostructure of jatropham dimer, the plain structure of which was presented previously, was confirmed by X-ray crystallographic analysis. The inhibitory activity on cyclic AMP phosphodiesterase of the steroidal saponins was evaluated.