The experience of bedaquiline implementation at a decentralised clinic in South Africa

被引:10
作者
Cariem, R. [1 ]
Cox, V. [2 ]
de Azevedo, V. [3 ]
Hughes, J. [2 ]
Mohr, E. [2 ]
Duran, L. Trivino [2 ]
Ndjeka, N. [4 ]
Furin, J. [5 ]
机构
[1] Nolungile Clin, City Hlth, Cape Town, South Africa
[2] Med Sans Frontieres, Cape Town, South Africa
[3] City Hlth, Cape Town, South Africa
[4] Natl Dept Hlth, TB & HIV AIDS Div, Pretoria, South Africa
[5] Harvard Med Sch, Dept Global Hlth & Social Med, 651 Huntington Ave,3rd Floor, Boston, MA 02115 USA
关键词
MDR-TB; BDQ; decentralised; Nolungile; Khayelitsha;
D O I
10.5588/pha.16.0037
中图分类号
R56 [呼吸系及胸部疾病];
学科分类号
摘要
Multidrug-resistant tuberculosis (MDR-TB) is a serious public health problem, but the new drugs bedaquiline (BDQ) and delamanid offer hope to improve outcomes and minimise toxicity. In Khayelitsha, South Africa, patients are routinely started on BDQ in the out-patient setting. This report from the field describes BDQ use in the out-patient setting at the Nolungile Clinic. The clinic staff overall report a positive experience using the drug. Challenges have been based largely on the logistics of drug supply and delivery. BDQ can be started successfully in the out-patient setting, and can be a positive experience for both patients and providers.
引用
收藏
页码:190 / 192
页数:3
相关论文
共 9 条
[1]
Multidrug Resistant Pulmonary Tuberculosis Treatment Regimens and Patient Outcomes: An Individual Patient Data Meta-analysis of 9,153 Patients [J].
Ahuja, Shama D. ;
Ashkin, David ;
Avendano, Monika ;
Banerjee, Rita ;
Bauer, Melissa ;
Bayona, Jamie N. ;
Becerra, Mercedes C. ;
Benedetti, Andrea ;
Burgos, Marcos ;
Centis, Rosella ;
Chan, Eward D. ;
Chiang, Chen-Yuan ;
Cox, Helen ;
D'Ambrosio, Lia ;
DeRiemer, Kathy ;
Nguyen Huy Dung ;
Enarson, Donald ;
Falzon, Dennis ;
Flanagan, Katherine ;
Flood, Jennifer ;
Garcia-Garcia, Maria L. ;
Gandhi, Neel ;
Granich, Reuben M. ;
Hollm-Delgado, Maria G. ;
Holtz, Timothy H. ;
Iseman, Michael D. ;
Jarlsberg, Leah G. ;
Keshavjee, Salmaan ;
Kim, Hye-Ryoun ;
Koh, Won-Jung ;
Lancaster, Joey ;
Lange, Christophe ;
de lange, Wiel C. M. ;
Leimane, Vaira ;
Leung, Chi Chiu ;
Li, Jiehui ;
Menzies, Dick ;
Migliori, Giovanni B. ;
Mishustin, Sergey P. ;
Mitnick, Carole D. ;
Narita, Masa ;
O'Riordan, Philly ;
Pai, Madhukar ;
Palmero, Domingo ;
Park, Seung-kyu ;
Pasvol, Geoffrey ;
Pena, Jose ;
Perez-Guzman, Carlos ;
Quelapio, Maria I. D. ;
Ponce-de-Leon, Alfredo .
PLOS MEDICINE, 2012, 9 (08)
[2]
[Anonymous], 2013, WHOHTMTB20136
[3]
[Anonymous], 2014, US DEL TREATM MULT R
[4]
Outcomes of Multi-Drug Resistant Tuberculosis (MDR-TB) among a Cohort of South African Patients with High HIV Prevalence [J].
Farley, Jason E. ;
Ram, Malathi ;
Pan, William ;
Waldman, Stacie ;
Cassell, Gail H. ;
Chaisson, Richard E. ;
Weyer, Karin ;
Lancaster, Joey ;
Van der Walt, Martie .
PLOS ONE, 2011, 6 (07)
[5]
Furin J, 2016, EMERG INFECT DIS, V22
[6]
Treatment of drug-resistant tuberculosis with bedaquiline in a high HIV prevalence setting: an interim cohort analysis [J].
Ndjeka, N. ;
Conradie, F. ;
Schnippel, K. ;
Hughes, J. ;
Bantubani, N. ;
Ferreira, H. ;
Maartens, G. ;
Mametja, D. ;
Meintjes, G. ;
Padanilam, X. ;
Variava, E. ;
Pym, A. ;
Pillay, Y. .
INTERNATIONAL JOURNAL OF TUBERCULOSIS AND LUNG DISEASE, 2015, 19 (08) :979-985
[7]
Noeske J, 2015, DRUG RESISTANT TB RE
[8]
Stinson K, 2016, INT J EPIDEMIOL
[9]
World Health Organization, 2015, WHOHTMTB201522