ICAM-1 TISSUE OVEREXPRESSION ASSOCIATED WITH INCREASED SERUM LEVELS OF ITS SOLUBLE FORM IN HODGKINS-DISEASE

被引：43

作者：

PIZZOLO, G

VINANTE, F

NADALI, G

RICETTI, MM

MOROSATO, L

MARROCCHELLA, R

VINCENZI, C

SEMENZATO, G

CHILOSI, M

机构：

[1] UNIV PADUA,SCH MED,MED CLIN 1,I-35100 PADUA,ITALY

[2] UNIV PADUA,SCH MED,CLIN IMMUNOL SECT,I-35100 PADUA,ITALY

[3] VERONA UNIV,SCH MED,DEPT HAEMATOL,VERONA,ITALY

[4] VERONA UNIV,SCH MED,DEPT PATHOL,VERONA,ITALY

来源：

BRITISH JOURNAL OF HAEMATOLOGY | 1993年 / 84卷 / 01期

关键词：

D O I：

10.1111/j.1365-2141.1993.tb03040.x

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

We investigated ICAM-1/CD54 tissue immunoreactivity and serum levels of its soluble form (sICAM-1) in patients with Hodgkin's disease (HD) at diagnosis. ICAM-1 was strongly expressed in involved tissues, and sICAM-1 serum levels were higher in HD (79 patients) than in controls (P<0.01), and in patients with more advanced or more active disease (stages III+IV v I+II: P=0.002: stage 'B' v 'A': P<0.0001; 'bulky' disease v non-'bulky': P=0.042). We suggest that tissue ICAM-1 overexpression leading to increase of circulating sICAM-1 may interfere with the lymphocyte adhesion machinary thus contributing to the well-known immune derangement of HD.

引用

页码：161 / 162

页数：2

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