ALZHEIMERS BETA-AMYLOID PEPTIDE SPECIFICALLY INTERACTS WITH AND IS DEGRADED BY INSULIN DEGRADING ENZYME

被引：344

作者：

KUROCHKIN, IV ^{[1
]}

GOTO, S ^{[1
]}

机构：

[1] TOHO UNIV,SCH PHARMACEUT SCI,DEPT BIOCHEM,FUNABASHI,CHIBA 274,JAPAN

来源：

FEBS LETTERS | 1994年 / 345卷 / 01期

关键词：

ALZHEIMERS DISEASE; BETA-AMYLOID; INSULIN DEGRADING ENZYME; OXIDATIVE MODIFICATION; PROTEIN DEGRADATION; BRAIN; RAT;

D O I：

10.1016/0014-5793(94)00387-4

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Cerebral deposition of beta-amyloid peptide (beta A) is a hallmark of Alzheimer's disease. Concentration of beta A could play a critical role in the rate of amyloid deposition. It is therefore of considerable importance to identify proteases involved in processing of beta A. I-125-labeled synthetic beta A specifically cross-linked to a single protein with M(r) = 110,000 in cytosol fractions from rat brain and liver. This protein was identified as insulin degrading enzyme (IDE) since the labeling of the 110 kDa protein was completely blocked by an excess of insulin, and anti-IDE monoclonal antibodies precipitated the labeled protein. Purified rat IDE effectively degraded beta A.

引用

页码：33 / 37

页数：5

共 29 条

[1]

BARROW CJ, 1992, J MOL BIOL, V225, P1975

[2] INSULIN AS AN AMYLOID-FIBRIL PROTEIN AT SITES OF REPEATED INSULIN INJECTIONS IN A DIABETIC PATIENT [J].

DISCHE, FE ;

WERNSTEDT, C ;

WESTERMARK, GT ;

WESTERMARK, P ;

PEPYS, MB ;

RENNIE, JA ;

GILBEY, SG ;

WATKINS, PJ .

DIABETOLOGIA, 1988, 31 (03) :158-161

[3]

DUCKWORTH WC, 1988, J BIOL CHEM, V263, P1826

[4]

FAGAN JM, 1992, J BIOL CHEM, V267, P23015

[5] A 109-AMINO-ACID C-TERMINAL FRAGMENT OF ALZHEIMERS-DISEASE AMYLOID PRECURSOR PROTEIN CONTAINS A SEQUENCE, -RHDS-, THAT PROMOTES CELL-ADHESION [J].

GHISO, J ;

ROSTAGNO, A ;

GARDELLA, JE ;

LIEM, L ;

GOREVIC, PD ;

FRANGIONE, B .

BIOCHEMICAL JOURNAL, 1992, 288 :1053-1059

[6] ALZHEIMERS-DISEASE - INITIAL REPORT OF THE PURIFICATION AND CHARACTERIZATION OF A NOVEL CEREBROVASCULAR AMYLOID PROTEIN [J].

GLENNER, GG ;

WONG, CW .

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 1984, 120 (03) :885-890

[7] PROCESSING OF THE AMYLOID PROTEIN-PRECURSOR TO POTENTIALLY AMYLOIDOGENIC DERIVATIVES [J].

GOLDE, TE ;

ESTUS, S ;

YOUNKIN, LH ;

SELKOE, DJ ;

YOUNKIN, SG .

SCIENCE, 1992, 255 (5045) :728-730

[8] CHARACTERIZATION AND CHROMOSOMAL LOCALIZATION OF A CDNA-ENCODING BRAIN AMYLOID OF ALZHEIMERS-DISEASE [J].

GOLDGABER, D ;

LERMAN, MI ;

MCBRIDE, OW ;

SAFFIOTTI, U ;

GAJDUSEK, DC .

SCIENCE, 1987, 235 (4791) :877-880

[9] AMYLOID BETA-PEPTIDE IS PRODUCED BY CULTURED-CELLS DURING NORMAL METABOLISM [J].

HAASS, C ;

SCHLOSSMACHER, MG ;

HUNG, AY ;

VIGOPELFREY, C ;

MELLON, A ;

OSTASZEWSKI, BL ;

LIEBERBURG, I ;

KOO, EH ;

SCHENK, D ;

TEPLOW, DB ;

SELKOE, DJ .

NATURE, 1992, 359 (6393) :322-325

[10] TARGETING OF CELL-SURFACE BETA-AMYLOID PRECURSOR PROTEIN TO LYSOSOMES - ALTERNATIVE PROCESSING INTO AMYLOID-BEARING FRAGMENTS [J].

HAASS, C ;

KOO, EH ;

MELLON, A ;

HUNG, AY ;

SELKOE, DJ .

NATURE, 1992, 357 (6378) :500-503

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