UTILIZATION OF L-SERINE IN AN OXIME OLEFIN CYCLOADDITION ROUTE TO A FUNCTIONALIZED ASYMMETRIC PYRROLIDINE, A SELECTIVE ALPHA-GLUCOSIDASE INHIBITOR

被引：37

作者：

HASSNER, A

FALB, E

NUDELMAN, A

ALBECK, A

GOTTLEIB, HE

机构：

[1] Department of Chemistry, Bar Ilan University, Ramat Gan

来源：

TETRAHEDRON LETTERS | 1994年 / 35卷 / 15期

关键词：

D O I：

10.1016/0040-4039(94)85229-4

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A new route for asymmetric aza-sugar analogs starting with L-serine and utilizing an intramolecular oxime olefin cycloaddition has been successfully developed. A member of this family of branched chain sugar amino di(hydroxymethyl) pyrrolidines (1 and 2) exhibits selective inhibition of alpha-glucosidase, while no inhibition of beta-glucosidase was detected.

引用

页码：2397 / 2400

页数：4

共 24 条

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