STABILITY OF OMEPRAZOLE SOLUTIONS AT VARIOUS PH VALUES AS DETERMINED BY HIGH-PERFORMANCE LIQUID-CHROMATOGRAPHY

被引：87

作者：

MATHEW, M ^{[1
]}

DASGUPTA, V ^{[1
]}

BAILEY, RE ^{[1
]}

机构：

[1] BEN TAUB GEN HOSP,HOUSTON,TX 77030

来源：

DRUG DEVELOPMENT AND INDUSTRIAL PHARMACY | 1995年 / 21卷 / 08期

关键词：

D O I：

10.3109/03639049509026660

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

A stability-indicating HPLC assay method for the quantitation of omeprazole has been developed. The developed method was used to study the effect of pH on the stability of omeprazole and to quantify the drug in capsules. The excipients present in the capsules did not interfere with the assay procedure. The pH-rate profile curve indicated that the maximum stability was at pH 11. Below pH 7.8, the decomposition was very fast. The decomposition constants have a direct relationship with the H+ concentrations of the solutions.

引用

页码：965 / 971

页数：7