BACTERICIDAL ACTIVITIES OF DU-6859A AND CLINAFLOXACIN (CI-960) AGAINST STAPHYLOCOCCI

被引：6

作者：

FORSTALL, GJ ^{[1
]}

KNAPP, CC ^{[1
]}

WASHINGTON, JA ^{[1
]}

机构：

[1] CLEVELAND CLIN FDN,DEPT CLIN PATHOL,MICROBIOL SECT,CLEVELAND,OH 44195

来源：

ANTIMICROBIAL AGENTS AND CHEMOTHERAPY | 1994年 / 38卷 / 08期

关键词：

D O I：

10.1128/AAC.38.8.1868

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

Timed killing curves were calculated at concentrations of 2 and 8 times the MICs of DU-6859a and clinafloxacin against six isolates of Staphylococcus aureus. Both quinolones produced a decrease in the log(10) CFU per milliliter of greater than or equal to 3 within 3 h at 2 and 8 times the MIC for the ciprofloxacin-susceptible isolates and at 8 times the MIC for the ciprofloxacin-resistant isolates; however, only 8 times the MIC of DU-6859a consistently prevented regrowth of all isolates after 24 h of incubation.

引用

页码：1868 / 1870

页数：3

共 9 条

[1] INVITRO ANTISTAPHYLOCOCCAL ACTIVITIES OF 2 INVESTIGATIVE FLUOROQUINOLONES, CI-960 AND WIN-57273, COMPARED WITH THOSE OF CIPROFLOXACIN, MUPIROCIN (PSEUDOMONIC ACID), AND PEPTIDE-CLASS ANTIMICROBIAL AGENTS [J].

ALDRIDGE, KE .

ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, 1992, 36 (04) :851-853

[2]

[Anonymous], 1993, METHODS DILUTION ANT

[3]

Hooper David C., 1993, P53

[4] CI-960, A NEW FLUOROQUINOLONE, FOR THERAPY OF EXPERIMENTAL CIPROFLOXACIN-SUSCEPTIBLE AND -RESISTANT STAPHYLOCOCCUS-AUREUS ENDOCARDITIS [J].

KAATZ, GW ;

SEO, SM ;

LAMP, KC ;

BAILEY, EM ;

RYBAK, MJ .

ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, 1992, 36 (06) :1192-1197

[5]

LEVIN CS, 1988, J ANTIMICROB CHEM SC, V22, P1

[6]

NAKASHIMA M, 1993, ANTIMICROB AGENTS CH

[7] ANTIMICROBIAL ACTIVITY OF DU-6859, A NEW POTENT FLUOROQUINOLONE, AGAINST CLINICAL ISOLATES [J].

SATO, K ;

HOSHINO, K ;

TANAKA, M ;

HAYAKAWA, I ;

OSADA, Y .

ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, 1992, 36 (07) :1491-1498

[8] EFFECT OF ANTIBIOTIC CARRY-OVER ON BACTERIAL COUNTING BY SPIRAL PLATING [J].

YOURASSOWSKY, E ;

VANDERLINDEN, MP ;

CROKAERT, F ;

GLUPCZYNSKI, Y .

JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY, 1988, 21 (01) :138-140

[9] PROTECTIVE EFFECT OF AMDINOCILLIN AGAINST EMERGENCE OF RESISTANCE TO CEFTAZIDIME IN ENTEROBACTER-CLOACAE [J].

YOURASSOWSKY, E ;

VANDERLINDEN, MP ;

LISMONT, MJ ;

CROKAERT, F ;

GLUPCZYNSKI, Y .

ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, 1988, 32 (11) :1632-1635

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