IMPROVED IMMUNOGENICITY OF ORAL DXRRV REASSORTANT ROTAVIRUS VACCINE BY LACTOBACILLUS-CASEI GG

被引：264

作者：

ISOLAURI, E

JOENSUU, J

SUOMALAINEN, H

LUOMALA, M

VESIKARI, T

机构：

[1] UNIV TAMPERE,DEPT BIOMED SCI,SF-33101 TAMPERE,FINLAND

[2] UNIV TAMPERE,DEPT CLIN MED,TAMPERE,FINLAND

来源：

VACCINE | 1995年 / 13卷 / 03期

基金：

美国国家卫生研究院;

关键词：

ROTAVIRUS VACCINE; LACTOBACILLUS; IMMUNOGENICITY; ADJUVANTS;

D O I：

10.1016/0264-410X(95)93319-5

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

In a search for new strategies to improve oral vaccination, the effect of orally administered Lactobacillus casei strain GG (LGG) in conjunction with DxRRV rhesus-human reassortant live oral rotavirus vaccine was tested in 2-5-month-old infants. Infants who received LGG showed an increased response with regard to rotavirus-specific IgM secreting cells, measured using an ELISPOT technique, on day 8 after vaccination. In infants receiving LGG or placebo, respectively, a rotavirus IgM seroconversion was dectected in 26/27 (96%) versus 23/27 (85%) cases (p=0.15) and rotavirus IgA seroconversion was detected in 26/28 (93%) versus 20/27 (74%) cases (p=0.05). These findings suggest that LGG has an immunostimulating effect on oral rotavirus vaccination. The clinical significance of LGG-enhanced immune responses to oral vaccines should be further evaluated.

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页码：310 / 312

页数：3

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