A STUDY OF NEW BIS(MACROCYCLIC POLYAMINE) LIGANDS AS INORGANIC AND ORGANIC ANION RECEPTORS

Propylene-bridged bisdioxo[16]aneN5(4b) and diether-bridged (5a) and propylene-bridged (5b) bis[16]aneN5ligands [bis(macrocyclic pentaamine)] were synthesized as host molecules for inorganic and organic anion guests. By the polarographic and potentiometric methods, 4b (di- and tetraprotonated) and 5a and 5b (tetra- and hexaprotonated) were found to yield stable 1:1 complexes with citrate3-, AMP2-, ATP4-, HP042-, [Fe(CN)6]4_, and [Fe(CN)6]3- anions. Comparison of these association constants (K) with those of the parent monomeric polyamines reveals that the attachment of the second polyamine moiety always enhances anion encapsulating abilities, suggesting the formation of sandwich-type complexes. Diprotonated tetraoxo[24]aneN86, [6•(H+)2]2+, forms more stable 1:1 complexes with nucleotide anions than the diprotonated 4b, [4b-(H+)2]2+. © 1990, American Chemical Society. All rights reserved.