INTERFERON INDUCERS INCREASE O-6-ALKYLGUANINE-DNA ALKYLTRANSFERASE IN THE RAT-LIVER

被引：18

作者：

BERTINI, R ^{[1
]}

COCCIA, P ^{[1
]}

PAGANI, P ^{[1
]}

MARINELLO, C ^{[1
]}

SALMONA, M ^{[1
]}

DINCALCI, M ^{[1
]}

机构：

[1] MARIO NEGRI INST PHARMACOL RES,VIA ERITREA 62,I-20157 MILAN,ITALY

来源：

CARCINOGENESIS | 1990年 / 11卷 / 01期

关键词：

D O I：

10.1093/carcin/11.1.181

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

We investigated whether treatment with the interferon inducer polyinosinic-polycytidylic acid and other cytokines (interleukin-1, tumor necrosis factor) or the cytokine inducer lipopolysaccharide modified 06-alkylguanine-DNA alkyltransferase (AT) in rat liver. AT levels were determined in liver extracts using N-[3H] methly-N-nitrosourea alkylated calf thymus DNA as substrate and an HPLC procedure to measure 06-methylguanine. Doses as low as 0.1 mg/kg i.p. of polyinosinic-polycytidylic acid caused a highly significant increase (P < 0.01) in AT levels in the liver, evident either 24 or 48 h after treatment. Lipopolysaccharide at the dose of 80 μg/kg i.p. also induced AT whereas interleukin-1 (60 μg/kg) or tumor necrosis factor (60 μg/kg) were inactive. Treatment with human recombinant interferon alpha A/D caused a highly significant increase in AT levels, thus confirming the hypothesis that interferon was probably responsible for the observed effect. These results suggest a link between the immune response and DNA repair mechanisms. © 1990 Oxford University Press.

引用

页码：181 / 183

页数：3

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