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INHIBITION OF ISOLATION-INDUCED AGGRESSIVE-BEHAVIOR WITH GABA TRANSAMINASE INHIBITORS

被引：35
作者：
DAVANZO, JP [1 ]
SYDOW, M [1 ]
机构：
[1] E CAROLINA UNIV, SCH MED, GREENVILLE, NC 27834 USA
来源：
PSYCHOPHARMACOLOGY | 1979年 / 62卷 / 01期
关键词：
γ-Acetylenic GABA; Aminooxyacetic acid; GABA; Isolation-induced aggressive behavior;
D O I：
10.1007/BF00426030
中图分类号：
Q189 [神经科学];
学科分类号：
071006 ;
摘要：
Administration of aminooxyacetic acid (AOAA) and .gamma.-acetylenic GABA (GAG) resulted in a dose-dependent suppression of aggressive behavior and a concomitant increase in brain GABA in mice. The increase in GABA levels persisted beyond the time when AOAA and GAG exerted an anti-aggressive effect. Brain GABA levels remained significantly elevated over controls for 120 h after a single AOAA injection and 46 h after a single GAG dose.
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页码：23 / 27
页数：5
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