EXPRESSION OF EPSTEIN-BARR VIRUS-ENCODED PROTEINS AND B-CELL MARKERS IN FATAL INFECTIOUS-MONONUCLEOSIS

被引：41

作者：

FALK, K

ERNBERG, I

SAKTHIVEL, R

DAVIS, J

CHRISTENSSON, B

LUKA, J

OKANO, M

GRIERSON, HL

KLEIN, G

PURTILO, DT

机构：

[1] UNIV NEBRASKA,MED CTR,DEPT PATHOL & MICROBIOL,600 SO 42ND ST,OMAHA,NE 68105

[2] KAROLINSKA INST,DEPT TUMOR BIOL,S-10401 STOCKHOLM 60,SWEDEN

[3] KAROLINSKA HOSP,DEPT PATHOL,S-10401 STOCKHOLM 60,SWEDEN

[4] UNIV NEBRASKA,MED CTR,EPPLEY INST RES CANC & ALLIED DIS,OMAHA,NE 68105

[5] UNIV NEBRASKA,MED CTR,DEPT PEDIAT,OMAHA,NE 68105

来源：

INTERNATIONAL JOURNAL OF CANCER | 1990年 / 46卷 / 06期

关键词：

D O I：

10.1002/ijc.2910460605

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

We assessed 33 lymphoid tissues from 15 patients, including 7 with X‐linked lymphoproliferative disease (XLP) and 8 pa tients with sporadic fatal infectious mononucleosis (IM), to determine whether the cellular infiltrate had the immu nophenotype and expressed Epstein‐Barr virus (EBV)‐encoded proteins characteristic of either EBV‐immortalized lymphoblastoid cell lines (LCL) or EBV‐carrying Burkitt lymphoma (BL) cells. The results of these studies revealed that in 13 cases the proliferating B cells were polyclonal, LCL‐like, and in 2 cases they were monoclonal, malignant lymphomalike. Copyright © 1990 Wiley‐Liss, Inc., A Wiley Company

引用

页码：976 / 984

页数：9

共 52 条

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