GENE-MAPPING OF MOUSE LAMININ A-SUBUNIT AND B2-SUBUNIT USING MOUSE CHINESE-HAMSTER SOMATIC-CELL HYBRIDS

被引：4

作者：

KAYE, NW

CHUNG, AE

LALLEY, PA

DURKIN, ME

PHILLIPS, SL

CHURCH, RL

机构：

[1] UNIV PITTSBURGH,DEPT BIOL SCI,PITTSBURGH,PA 15260

[2] INST MED RES,BENNINGTON,VT

[3] UNIV PITTSBURGH,DEPT MICROBIOL,PITTSBURGH,PA 15260

[4] EMORY UNIV,SCH MED,DEPT OPHTHALMOL,ATLANTA,GA 30322

来源：

SOMATIC CELL AND MOLECULAR GENETICS | 1990年 / 16卷 / 06期

关键词：

D O I：

10.1007/BF01233101

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Laminin is a multichain extracellular matrix glycoprotein found primarily in basement membranes. The molecule is made up of three subunits, designated as A, B1, and B2. Using an 850-base cDNA probe for the mouse laminin A-chain and a 1000-base cDNA probe for the mouse laminin B2 chain, we have screened mouse-Chinese hamster somatic cell hybrids in order to assign the genes for each of these polypeptides to their respective mouse chromosome. We have determined that the mouse laminin B2-chain gene is located on chromosome 1 (confirming this assignment) and the laminin A-chain gene is located on chromosome 17.

引用

页码：599 / 603

页数：5

共 23 条

[1] GENERAL METHOD FOR ISOLATION OF HIGH MOLECULAR-WEIGHT DNA FROM EUKARYOTES [J].