9 + 0 AXONEME IN SPERMATOZOA AND SOME NASAL CILIA OF A PATIENT WITH TOTALLY IMMOTILE SPERMATOZOA ASSOCIATED WITH THICKENED SHEATH AND SHORT MIDPIECE

被引:32
作者
NEUGEBAUER, DC [1 ]
NEUWINGER, J [1 ]
JOCKENHOVEL, F [1 ]
NIESCHLAG, E [1 ]
机构
[1] INST MED CYTOBIOL,W-4400 MUNSTER,GERMANY
关键词
ELECTRON MICROSCOPY; IMMOTILE SPERM; MOTILITY;
D O I
10.1093/oxfordjournals.humrep.a137232
中图分类号
R71 [妇产科学];
学科分类号
100211 ;
摘要
A patient is described with 100% immotile spermatozoa. The sperm cells lack the central pair of microtubules or the complete axoneme. This defect is associated with a thickened fibrous sheath and a shortened midpiece containing defective mitochondria. Fifteen per cent of the nasal cilia of this patient lack the central pair of microtubules. Eighteen similar cases have been described in the literature suggesting that this association of ultrastructural defects may be considered a syndrome.
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收藏
页码:981 / 986
页数:6
相关论文
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  • [1] Afzelius B.J., Eliasson R., Flagellar mutants in man: On the heterogeneity of the immotile cilia syndrome, J. Ultrastruct. Res, 69, pp. 43-52, (1979)
  • [2] Afzelius B.J., Eliasson R., Johnson O., Lindholmer C., Lack of dynein arms in immotile human spermatozoa, J. Cell Biol, 66, pp. 225-232, (1975)
  • [3] Baccetti B., Burrini A.G., Dallai R., Pallini V., The dynein electrophoretic bands in axonemes naturally lacking the inner or outer arm, J. Cell Biol, 80, pp. 334-340, (1979)
  • [4] Baccetti B., Burrini A.G., Maver A., Pallini V., T. (1979b) ‘9 + 0’ immotile spermatozoa in an infertile man, Andrologia, 11, pp. 437-443
  • [5] Baccetti B., Burrini A.G., Pallini V., Spermatozoa and cilia lacking axoneme in an infertile man, Andrologia, 12, pp. 525-532, (1980)
  • [6] Brokaw C.J., Lude D.J., Bending patterns of Chlamydomonas Flagella III. A radial-spoke head deficient mutant and a central pair deficient mutation, Cell Motil, 5, pp. 195-208, (1985)
  • [7] Camner P., Mossberg B., Afzelius B.A., Measurements of trachobronchial clearance in patients with immotile-cilia syndrome and its value in differential diagnosis, Eur. J. Respir. Dis, 64, pp. 57-63, (1983)
  • [8] Dadoune J.P., Ultrastructuralabnormalities of human spermatozoa, Hum. Reprod, 3, pp. 311-318, (1988)
  • [9] Eliasson R., Mossberg B., Camner P., Afzelius B.A., The immotile cilia syndrome, New Engl. J. Med, 297, pp. 1-6, (1977)
  • [10] Escalier D., David G., Pathology of the cytoskeleton on the human sperm flagellum: Axonemal and peri-axonemal anomalies, Biol. Cell, 50, pp. 37-52, (1984)