THE ROLE OF ADENYLATE KINASE IN DYNAMIC COMPARTMENTATION OF ADENINE-NUCLEOTIDES IN THE MITOCHONDRIAL INTERMEMBRANE SPACE

被引:53
作者
GELLERICH, FN
机构
[1] Institut für Biochemie, Medizinische Akademie Magdeburg, O- 3090 Magdeburg
关键词
ADENYLATE KINASE; RAT HEART MITOCHONDRION; RAT LIVER MITOCHONDRION; COMPARTMENTATION; ADENINE NUCLEOTIDE; INTERMEMBRANE SPACE;
D O I
10.1016/0014-5793(92)80326-C
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
To investigate the existence of a dynamic adenine nucleotide (AdN) compartment in the mitochondrial intermembrane space, we used reconstituted systems consisting of (i) functional intact liver and heart mitochondria and (ii) pyruvate kinase plus phosphoenolpyruvate, both competing for ADP either formed in the intermembrane space by adenylate kinase or added directly into, or regenerated by ATPase within, the extramitochondrial space. It is shown that ADP formation in the mitochondrial intermembrane space is a prerequisite for a dominating oxidative phosphorylation in reconstituted systems, suggesting dynamic ADP compartmentation in that space.
引用
收藏
页码:55 / 58
页数:4
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