EFFECT OF OXIRACETAM ON SCOPOLAMINE-INDUCED AMNESIA IN THE RAT IN A SPATIAL-LEARNING TASK

被引：16

作者：

PITSIKAS, N ^{[1
]}

ALGERI, S ^{[1
]}

机构：

[1] MARIO NEGRI INST PHARMACOL RES,I-20157 MILAN,ITALY

来源：

PHARMACOLOGY BIOCHEMISTRY AND BEHAVIOR | 1992年 / 43卷 / 03期

关键词：

OXIRACETAM; NOOTROPIC DRUGS; SCOPOLAMINE; SPATIAL LEARNING; MORRIS WATER MAZE;

D O I：

10.1016/0091-3057(92)90430-N

中图分类号：

B84 [心理学]; C [社会科学总论]; Q98 [人类学];

学科分类号：

03 ; 0303 ; 030303 ; 04 ; 0402 ;

摘要：

The effects of the nootropic agent 4-hydroxy-2-oxopyrrolidinoacetamide (oxiracetam) on memory and performance impairments induced by scopolamine were evaluated in the Morris water maze task. No effect was seen on the performance of rats when treated with oxiracetam (30 mg/kg, IP) alone. Task performance of scopolamine (0.2 mg/kg, SC)-treated rats was impaired as compared to that of control animals. The behavioral deficits expressed in the task by scopolamine treatment were attenuated by the same dose of oxiracetam.

引用

页码：949 / 951

页数：3

共 19 条

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