DISTRIBUTION PROFILE AND PROPERTIES OF PERIPHERAL-TYPE BENZODIAZEPINE RECEPTORS ON HUMAN HEMATOPOIETIC-CELLS

被引：118

作者：

CANAT, X

CARAYON, P

BOUABOULA, M

CAHARD, D

SHIRE, D

ROQUE, C

LEFUR, G

CASELLAS, P

机构：

[1] SANOFI RECH, DEPT IMMUNOPHARMACOL, 371 RUE PROF JOSEPH BLAYAC, F-34184 MONTPELLIER 04, FRANCE

[2] SANOFI RECH, DEPT TOXICOL, F-34184 MONTPELLIER 14, FRANCE

[3] SANOFI ELF BIORECH, ORGAN CHEM UNIT, LABEGE, FRANCE

来源：

LIFE SCIENCES | 1993年 / 52卷 / 01期

关键词：

D O I：

10.1016/0024-3205(93)90293-C

中图分类号：

R-3 [医学研究方法]; R3 [基础医学];

学科分类号：

1001 ;

摘要：

The cellular localization of peripheral-type benzodiazepine receptors (PBRs) was characterized in several human blood cell subpopulations including erythrocytes, platelets, monocytes and polymorphonuclear neutrophils (PMN), B, NK, T8 and T4-cells. Pharmacological properties of the PBR were established by binding studies and PBR mRNA expression was measured by quantitative polymerase chain reaction based method. These data clearly indicate 1) the PBR is pharmacologically homogeneous in the various types of blood cells, 2) the rank order of PBR cell density is monocytes = PMN > lymphocytes >> platelets > erythrocytes, 3) the PBR appears to be transcriptionally regulated since mRNA levels are roughly correlated with PBR density.

引用

页码：107 / 118

页数：12

共 43 条

[1] CHARACTERIZATION OF PERIPHERAL-TYPE BENZODIAZEPINE BINDING-SITES ON HUMAN-LYMPHOCYTES AND LYMPHOMA CELL-LINES AND THEIR ROLE IN CELL-GROWTH [J].