CAJUCARINOLIDE AND ISOCAJUCARINOLIDE - ANTIINFLAMMATORY DITERPENES FROM CROTON-CAJUCARA

被引：36

作者：

ICHIHARA, Y

TAKEYA, K

HITOTSUYANAGI, Y

MORITA, H

OKUYAMA, S

SUGANUMA, M

FUJIKI, H

MOTIDOME, M

ITOKAWA, H

机构：

[1] TOKYO COLL PHARM, DEPT PHARMACOGNOSY, HORINOUCHI 1432-1, HACHIOJI, TOKYO 19203, JAPAN

[2] UNIV SAO PAULO, INST QUIM, BR-05508 SAO PAULO, BRAZIL

[3] NATL CANC CTR, DIV CANC PREVENT, CHUO KU, TOKYO 104, JAPAN

来源：

PLANTA MEDICA | 1992年 / 58卷 / 06期

关键词：

CAJUCARINOLIDE; ISOCAJUCARINOLIDE; CLERODANE DITERPENE; CROTON-CAJUCARA; EUPHORBIACEAE; PHOSPHOLIPASE-A2; INHIBITOR; ANTIINFLAMMATION; TELEOCIDIN;

D O I：

10.1055/s-2006-961547

中图分类号：

Q94 [植物学];

学科分类号：

071001 ;

摘要：

Cajucarinolide and isocajucarinolide, two new clerodane diterpenes, have been isolated from the cortices of Croton cajucara (Euphorbiaceae). These compounds possess anti-inflammatory activity and inhibit bee venom phospholipase A2 in vitro.

引用

页码：549 / 551

页数：3

共 18 条

[1] PHOSPHOLIPASE-A2 - FUNCTION AND PHARMACOLOGICAL REGULATION [J].

CHANG, J ;

MUSSER, JH ;

MCGREGOR, H .

BIOCHEMICAL PHARMACOLOGY, 1987, 36 (15) :2429-2436

[2]

CHILTON FH, 1984, J BIOL CHEM, V259, P2014

[3] BIOLOGICAL RELEVANCE OF LIPOCORTINS AND RELATED PROTEINS AS INHIBITORS OF PHOSPHOLIPASE-A2 [J].

DAVIDSON, FF ;

DENNIS, EA .

BIOCHEMICAL PHARMACOLOGY, 1989, 38 (21) :3645-3651

[4] CACOSPONGIONOLIDE - A NEW ANTITUMORAL SESTERTERPENE, FROM THE MARINE SPONGE CACOSPONGIA-MOLLIOR [J].

DEROSA, S ;

DESTEFANO, S .

JOURNAL OF ORGANIC CHEMISTRY, 1988, 53 (21) :5020-5023

[5]

FUJIKI H, 1989, ENVIRON CARCINOG REV, V7, P1

[6]

GLASER KB, 1989, MOL PHARMACOL, V36, P782

[7] CYTO-TOXIC DITERPENES FROM THE RHIZOMES OF HEDYCHIUM-CORONARIUM [J].

ITOKAWA, H ;

MORITA, H ;

KATOU, I ;

TAKEYA, K ;

CAVALHEIRO, AJ ;

DEOLIVEIRA, RCB ;

ISHIGE, M ;

MOTIDOME, M .

PLANTA MEDICA, 1988, (04) :311-315

[8] NOR-CLERODANE DITERPENES FROM CROTON-CAJUCARA [J].

ITOKAWA, H ;

ICHIHARA, Y ;

KOJIMA, H ;

WATANABE, K ;

TAKEYA, K .

PHYTOCHEMISTRY, 1989, 28 (06) :1667-1669

[9] EURYLENE, A NEW SQUALENE-TYPE TRITERPENE FROM EURYCOMA-LONGIFOLIA [J].

ITOKAWA, H ;

KISHI, E ;

MORITA, H ;

TAKEYA, K ;

IITAKA, Y .

TETRAHEDRON LETTERS, 1991, 32 (15) :1803-1804

[10] SOME PHARMACOLOGICAL OBSERVATIONS ON MARINE NATURAL-PRODUCTS [J].

JACOBS, RS ;

CULVER, P ;

LANGDON, R ;

OBRIEN, T ;

WHITE, S .

TETRAHEDRON, 1985, 41 (06) :981-984

← 1 2 →