CARCINOGENICITY OF POLICOSANOL IN SPRAGUE-DAWLEY RATS - A 24-MONTH STUDY

被引：30

作者：

ALEMAN, CL

FERREIRO, RM

PUIG, MN

GUERRA, IR

ORTEGA, CH

CAPOTE, A

机构：

[1] Center of Natural Products, National Center for Scientific Research, Havana

来源：

TERATOGENESIS CARCINOGENESIS AND MUTAGENESIS | 1994年 / 14卷 / 05期

关键词：

ATEROMIXOL; CARCINOGENICITY; CHOLESTEROL-LOWERING DRUG; HIGHER ALIPHATIC ALCOHOLS; TYPE II HYPERLIPOPROTEINEMIA; SPRAGUE DAWLEY RATS; SUGAR CANE WAX; POLICOSANOL;

D O I：

10.1002/tcm.1770140505

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

The effects of policosanol (50-500 mg/kg) administered orally for 24 months to Sprague Dawley rats of both sexes were investigated. No differences related to daily clinical observations, weight gain, food consumption, or mortality (survival analysis) between groups were found. Histopathological study showed that the frequency of the occurrence of non-neoplastic and neoplastic (benign and malignant) lesions was similar in the control and policosanol-treated groups. The lesions observed in this study were similar to the spontaneous lesions reported in this species in previous studies. Since no drug-related increase in the occurrence of malignant or benign neoplasms was found, nor acceleration in tumors growth in any specific group was observed, this study shows no evidence of policosanol induced carcinogenicity in this strain of rats. (C) 1994 Wiley-Liss, Inc.

引用

页码：239 / 249

页数：11

共 27 条

[1] A 12-MONTH STUDY OF POLICOSANOL ORAL TOXICITY IN SPRAGUE-DAWLEY RATS [J].

ALEMAN, CL ;

MAS, R ;

HERNANDEZ, C ;

RODEIRO, I ;

CEREJIDO, E ;

NOA, M ;

CAPOTE, A ;

MENENDEZ, R ;

AMOR, A ;

FRAGA, V ;

SOTOLONGO, V ;

JIMENEZ, S .

TOXICOLOGY LETTERS, 1994, 70 (01) :77-87

[2]

ALEMAN CL, 1992, 6 INT C TOX ROM JUN, P248

[3]

Arruzazabala M. L., 1991, REV CENIC CIENC BIOL, V22, P60

[4]

ARRUZAZABALA MD, 1992, ARCH VENEZOLANOS FAR, V11, P2

[5]

CASTANO G, 1991, PCM-PREM PERS COMPUT, V5, P21

[6] AN OVERVIEW OF PRECHRONIC AND CHRONIC TOXICITY CARCINOGENICITY EXPERIMENTAL-STUDY DESIGNS AND CRITERIA USED BY THE NATIONAL TOXICOLOGY PROGRAM [J].

CHHABRA, RS ;

HUFF, JE ;

SCHWETZ, BS ;

SELKIRK, J .

ENVIRONMENTAL HEALTH PERSPECTIVES, 1990, 86 :313-321

[7] THE CLASSIFICATION OF CARCINOGENS IDENTIFIED IN THE RODENT BIOASSAY AS POTENTIAL RISKS TO HUMANS - WHAT TYPE OF SUBSTANCE SHOULD BE TESTED NEXT [J].

CLAYSON, DB ;

ARNOLD, DL .

MUTATION RESEARCH, 1991, 257 (01) :91-106

[8]

Cruz-Bustillo D, 1991, REV CENIC CIENC BIOL, V22, P62

[9]

DURBIN PW, 1966, CANCER RES, V26, P400

[10]

ELETREBY MF, 1988, PATHOL RES PRACT, V183, P645

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