The Use of Porphyrins in Photodynamic Therapy of Cutaneous Leishmaniasis

被引：10

作者：

Bastos, Monica M. ^{[1
]}

Boechat, Nubia ^{[1
]}

Gomes, Ana T. P. C. ^{[2
]}

Neves, Maria G. P. M. S. ^{[2
]}

Cavaleiro, Jose A. S. ^{[2
]}

机构：

[1] Fundacao Oswaldo Cruz, Inst Tecnol Farmacos, Dept Sintese Organ, BR-21041250 Rio De Janeiro, RJ, Brazil

[2] Univ Aveiro, Dept Quim, QOPNA, P-3810193 Aveiro, Portugal

来源：

REVISTA VIRTUAL DE QUIMICA | 2012年 / 4卷 / 03期

关键词：

Porphyrins; cutaneous leishmaniasis; neglected diseases; photodynamic therapy;

D O I：

10.5935/1984-6835.20120021

中图分类号：

O6 [化学];

学科分类号：

0703 [化学];

摘要：

Leishmaniasis is a disease transmitted by protozoa of the genus Leishmania. Numerous species are responsible for the infection in humans, resulting in three clinical phenotypes. The therapeutic drug availability for treatment of this endemic disease is still limited and presents several problems. Photodynamic therapy (PDT) is presented as an alternative action for the treatment of cutaneous leishmaniasis (CL). Studies suggest that this therapy using porphyrins is relatively effective in the treatment of CL. However, data are still limited and PDT can not yet be recommended in clinical routine practice. Moreover, the mechanism of action of this promising therapy still needs to be investigated.

引用

页码：257 / 267

页数：11

共 55 条

[1]

Parasiticidal effect of δ-aminolevulinic acid-based photodynamic therapy for cutaneous leishmaniasis is indirect and mediated through the killing of the host cells [J].

Akilov, Oleg E. ;

Kosaka, Sachiko ;

O'Riordan, Katie ;

Hasan, Tayyaba .

EXPERIMENTAL DERMATOLOGY, 2007, 16 (08) :651-660

[2]

Clinical PD/PDT in North America: An historical review [J].

Allison, R. R. ;

Mota, H. C. ;

Sibata, C. H. .

PHOTODIAGNOSIS AND PHOTODYNAMIC THERAPY, 2004, 1 (04) :263-277

[3]

Cutaneous and mucocutaneous leishmaniasis: emerging therapies and progress in disease management [J].

Ameen, Mahreen .

EXPERT OPINION ON PHARMACOTHERAPY, 2010, 11 (04) :557-569

[4]

A Randomized Controlled Trial of Local Heat Therapy Versus Intravenous Sodium Stibogluconate for the Treatment of Cutaneous Leishmania major Infection [J].

Aronson, Naomi E. ;

Wortmann, Glenn W. ;

Byrne, William R. ;

Howard, Robin S. ;

Bernstein, Wendy B. ;

Marovich, Mary A. ;

Polhemus, Mark E. ;

Yoon, In-Kyu ;

Hummer, Kelly A. ;

Gasser, Robert A., Jr. ;

Oster, Charles N. ;

Benson, Paul M. .

PLOS NEGLECTED TROPICAL DISEASES, 2010, 4 (03)

[5]

Comparison between the efficacy of photodynamic therapy and topical paromomycin in the treatment of Old World cutaneous leishmaniasis: a placebo-controlled, randomized clinical trial [J].

Asilian, A. ;

Davami, M. .

CLINICAL AND EXPERIMENTAL DERMATOLOGY, 2006, 31 (05) :634-637

[6]

Comparative study of the efficacy of combined cryotherapy and intralesional meglumine antimoniate (Glucantime®) vs. cryotherapy and intralesional meglumine antimoniate (Glucantime®) alone for the treatment of cutaneous leishmaniasis [J].

Asilian, A ;

Sadeghinia, A ;

Faghihi, G ;

Momeni, A .

INTERNATIONAL JOURNAL OF DERMATOLOGY, 2004, 43 (04) :281-283

[7]

Antiprotozoal compounds: state of the art and new developments [J].

Astelbauer, F. ;

Walochnik, J. .

INTERNATIONAL JOURNAL OF ANTIMICROBIAL AGENTS, 2011, 38 (02) :118-124

[8]

Photodynamic therapy in dermatology: state-of-the-art [J].

Babilas, Philipp ;

Schreml, Stephan ;

Landthaler, Michael ;

Szeimies, Rolf-Markus .

PHOTODERMATOLOGY PHOTOIMMUNOLOGY & PHOTOMEDICINE, 2010, 26 (03) :118-132

[9]

Lack of efficacy and tolerability of topical PDT for psoriasis in comparison with narrowband UVB phototherapy [J].

Beattie, PE ;

Dawe, RS ;

Ferguson, J ;

Ibbotson, SH .

CLINICAL AND EXPERIMENTAL DERMATOLOGY, 2004, 29 (05) :560-562

[10]

BERMAN JD, 1988, REV INFECT DIS, V10, P560

← 1 2 3 4 5 6 →