INVITRO AND INVIVO ENHANCEMENT OF VINCRISTINE ANTITUMOR-ACTIVITY ON B-16 MELANOMA-CELLS BY CALCIUM-ANTAGONIST FLUNARIZINE

被引：10

作者：

BELLELLI, A

CAMBONI, C

DELUCA, G

MATERAZZI, M

MATTIONI, M

SEZZI, ML

BELLELLI, L

机构：

[1] REGINA ELENA NATL CANC INST, FISIOPATOL LAB, VIALE REGINA ELENA 291, I-00161 Rome, ITALY

[2] UNIV ROME LA SAPIENZA, INST RADIOL, I-00185 ROME, ITALY

[3] POLIFARMA RES CTR, ROME, ITALY

来源：

ONCOLOGY | 1987年 / 44卷 / 01期

关键词：

D O I：

10.1159/000226436

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Flunarizine, a calcium antagonist commonly employed in therapy for vascular diseases, enhances the in vitro and in vivo antitumor activity of vincristine on B16 melanoma cells. In the presence of flunarizine higher intracellular levels of vincristine were observed in vitro and for a longer time. B16 melanoma bearing mice treated with both the drugs presented a median survival time that was significantly longer than that of the controls. The possible mechanism of the enhancement is herein discussed.

引用

页码：17 / 23

页数：7

共 22 条

[1]

AGGARWAL SK, 1980, CISPLATIN CURRENT ST, P79

[2]

COHEN SM, 1983, CANCER TREAT REP, V67, P947

[3]

CURT GA, 1984, CANCER TREAT REP, V68, P87

[4]

FERGUSON PJ, 1984, CANCER RES, V44, P3307

[5]

GANAPATHI R, 1983, CANCER RES, V43, P3696

[6]

GERAN RI, 1972, CANC CHEMOTHER REP, V3, P1

[7]

HINES RH, 1976, CANCER RES, V36, P3789

[8] INTERACTIONS OF CALMODULIN WITH COATED VESICLES FROM BRAIN [J].

LINDEN, CD ;

DEDMAN, JR ;

CHAFOULEAS, JG ;

MEANS, AR ;

ROTH, TF .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA-BIOLOGICAL SCIENCES, 1981, 78 (01) :308-312

[9]

MABEL JA, 1978, CANCER-AM CANCER SOC, V42, P1711, DOI 10.1002/1097-0142(197810)42:4<1711::AID-CNCR2820420409>3.0.CO

[10]

2-X

← 1 2 3 →