STUDIES ON MECHANISM OF ACTION OF SALICYLATES .4. EFFECT OF SALICYLATES ON OXIDATIVE PHOSPHORYLATION

被引：26

作者：

THOMPKIN.L

LEE, KH

机构：

[1] University of California, School of Pharmacy, San Francisco Medical Center, San Francisco, California

[2] Lilly Research Laboratories, Eli Lilly and Co, Indianapolis, Indiana

来源：

JOURNAL OF PHARMACEUTICAL SCIENCES | 1969年 / 58卷 / 01期

关键词：

Aspirin effect—oxidative‐phosphorylation uncoupling; Liver mitochondrial mixtures—aspirin hydrolysis; Oxidative‐phosphorylation uncoupling—salicylate effect; Salicylate activity—mechanism;

D O I：

10.1002/jps.2600580122

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

The hydrolysis of acetylsalicylic acid and the oxidative‐phosphorylation uncoupling activity of salicylic acid and acetylsalicylic acid in rat liver mitochondrial preparations at pH 7.4 and 25° have been studied. The rate of hydrolysis of acetylsalicylic acid in mitochondrial preparations under these conditions is fairly slow. The uncoupling activity observed in the presence of acetylsalicylic acid is due to the salicylic acid produced during the experiment. The results obtained in the present study support some recent findings on the effect of salicylates on several other biologic activities. Copyright © 1969 Wiley‐Liss, Inc., A Wiley Company

引用

页码：102 / &

共 26 条

[1]

Adams S.S., 1963, SALICYLATES, P127

[2] POSSIBLE BASIS FOR THE ANTI-INFLAMMATORY ACTIVITY OF SALICYLATES AND OTHER NON-HORMONAL ANTI-RHEUMATIC DRUGS [J].