DIFFERENTIAL EFFECTS OF LOCALIZED LESIONS OF N. ACCUMBENS ON MORPHINE-INDUCED AND AMPHETAMINE-INDUCED LOCOMOTOR HYPERACTIVITY IN THE C57BL-6J MOUSE

被引：50

作者：

TEITELBAUM, H

GIAMMATTEO, P

MICKLEY, GA

机构：

[1] US Armed Forces Radiobiology Research Inst, Bethesda, MD

来源：

JOURNAL OF COMPARATIVE AND PHYSIOLOGICAL PSYCHOLOGY | 1979年 / 93卷 / 04期

关键词：

dextroamphetamine induced locomotor hyperactivity; mice; haloperidol &; localized lesions &; spiroperidol blockade of nucleus accumbens; morphine;

D O I：

10.1037/h0077605

中图分类号：

B84 [心理学];

学科分类号：

04 ; 0402 ;

摘要：

In 2 experiments with 46 C57BL/6J mice, it was found that Ss became hyperactive to increasing doses of morphine sulfate. This response was similar to locomotor hyperactivity induced by amphetamine. Lesions and chemical blockade of posterior nucleus accumbens abolished amphetamine-induced hyperactivity and reduced but did not abolish the morphine response. Results demonstrate that response to the drugs is mediated by overlapping but noncongruent neural systems. (18 ref) (PsycINFO Database Record (c) 2006 APA, all rights reserved). © 1979 American Psychological Association.

引用

页码：745 / 751

页数：7

共 18 条

[1]

HARVEY JA, 1963, J PHARMACOL EXP THER, V140, P103

[2] AMPHETAMINE AND APOMORPHINE RESPONSES IN RAT FOLLOWING 6-OHDA LESIONS OF NUCLEUS ACCUMBENS SEPTI AND CORPUS STRIATUM [J].