INTERLEUKIN-2 (IL-2) INHIBITOR IN RHEUMATOID SYNOVIAL-FLUID - CORRELATION WITH PROGNOSIS AND SOLUBLE IL-2 RECEPTOR LEVELS

被引：11

作者：

MIOSSEC, P

ELHAMIANI, M

CHICHEHIAN, B

DANGEAC, AD

SANY, J

HIRN, M

机构：

[1] CTR GUI DE CHAULIAC,IMMUNORHEUMATOL UNIT,F-34059 MONTPELLIER,FRANCE

[2] INSERM,U291,F-34100 MONTPELLIER,FRANCE

[3] IMMUNOTECH LABS,MARSEILLE,FRANCE

[4] FAC SCI LUMINY,F-13288 MARSEILLE 9,FRANCE

来源：

JOURNAL OF CLINICAL IMMUNOLOGY | 1990年 / 10卷 / 02期

关键词：

interleukin 2 (IL 2) inhibitor; prognosis; Rheumatoid arthritis; soluble IL 2 receptors; synovial fluid;

D O I：

10.1007/BF00918193

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

A soluble activity inhibiting over 50% of the CTLL-2 cell line response to recombinant human interleukin 2 (IL 2) was found in 17 of 29 (59%) rheumatoid synovial fluids. To study the prognosis value of this activity, 16 rheumatoid synovial fluids were collected before a radiation synovectomy of the knee with 7 mCi of90Yt. Patients with a good clinical result after the synovectomy had a lower IL 2 inhibitory activity than those with a bad or uncomplete result (P<0.01). Levels of inhibitory activity and of soluble IL 2 receptors were correlated with each other and with the response of the synovitis to the radiation synovectomy. These results extend the clinical usefulness of soluble IL 2 receptor measurements and indicate a correlation between the immune activation of the rheumatoid synovitis and its clinical activity. © 1990 Plenum Publishing Corporation.

引用

页码：115 / 120

页数：6

共 22 条

[1] SERUM LEVELS OF INTERLEUKIN-2 RECEPTOR AND ACTIVITY OF RHEUMATIC DISEASES CHARACTERIZED BY IMMUNE-SYSTEM ACTIVATION [J].