DIFFERENCES IN INDUCTION OF SISTER CHROMATID EXCHANGES IN MNNG-RESISTANT HELA S3 MER- CELL-LINES

被引：12

作者：

ISHIDA, R ^{[1
]}

UTSUMI, KR ^{[1
]}

机构：

[1] AICHI CANC CTR,RES INST,ULTRASTRUCT RES LAB,NAGOYA,AICHI 464,JAPAN

来源：

CARCINOGENESIS | 1990年 / 11卷 / 07期

关键词：

D O I：

10.1093/carcin/11.7.1209

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

All N-methyl-N'-nitro-N-nitrosoguanidine (MNNG)-resistant (MR) cell lines of HeLa S3 Mer- cells tested were found to be defective in O6-methylgunine-DNA-methyltransferase and more sensitive than HeLa Mer+ cells to 1-(4-amino-2-methyl-5-pyrimidinyl)methyl-3-(2-chloroethyl)-1-nitroso-urea, like the parental HeLa S3 Mer- cells. MR10-1 amd MR1-3 cells were also highly resistant to induction of sister chromatid exchanges (SCEs) by MNNG, while MR6, MR8 and MR11 cells were slightly resistant to SCE induction. MR10-1 and MR1-3 cells showed higher spontaneous mutation rates than the parental cells. These results indicated that there are at least two types of MR cells. All MR cells were more sensitive than HeLa S3 Mer- cells to 6-hydroxy-amino purine. © 1990 Oxford University Press.

引用

页码：1209 / 1212

页数：4

共 35 条

[1] TOLERANCE TO METHYLNITROSOUREA-INDUCED DNA DAMAGE IS ASSOCIATED WITH 6-THIOGUANINE RESISTANCE IN CHO CELLS [J].

AQUILINA, G ;

ZIJNO, A ;

MOSCUFO, N ;

DOGLIOTTI, E ;

BIGNAMI, M .

CARCINOGENESIS, 1989, 10 (07) :1219-1223

[2] REDUCTION OF THE TOXICITY AND MUTAGENICITY OF ALKYLATING-AGENTS IN MAMMALIAN-CELLS HARBORING THE ESCHERICHIA-COLI ALKYLTRANSFERASE GENE [J].

BRENNAND, J ;

MARGISON, GP .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1986, 83 (17) :6292-6296

[3] DIFFERENT BASE BASE MISPAIRS ARE CORRECTED WITH DIFFERENT EFFICIENCIES AND SPECIFICITIES IN MONKEY KIDNEY-CELLS [J].

BROWN, TC ;

JIRICNY, J .

CELL, 1988, 54 (05) :705-711

[4] MODIFIED SV40 FOR ANALYSIS OF MISMATCH REPAIR IN SIMIAN AND HUMAN-CELLS [J].

BROWN, TC ;

ZBINDEN, I ;

CERUTTI, PA ;

JIRICNY, J .

MUTATION RESEARCH, 1989, 220 (2-3) :115-123

[5] SISTER CHROMATID EXCHANGE AS AN INDICATOR OF MUTAGENESIS [J].

CARRANO, AV ;

THOMPSON, LH ;

LINDL, PA ;

MINKLER, JL .

NATURE, 1978, 271 (5645) :551-553

[6] RE-EVALUATION OF HELA, HELA S3, AND HEP-2 KARYOTYPES [J].

CHEN, TR .

CYTOGENETICS AND CELL GENETICS, 1988, 48 (01) :19-24

[7] HUMAN-TUMOR CELL STRAINS DEFECTIVE IN THE REPAIR OF ALKYLATION DAMAGE [J].

DAY, RS ;

ZIOLKOWSKI, CHJ ;

SCUDIERO, DA ;

MEYER, SA ;

MATTERN, MR .

CARCINOGENESIS, 1980, 1 (01) :21-32

[8]

DAY RS, 1984, MUTAT RES, V131, P45

[9] DEFECTIVE REPAIR OF ALKYLATED DNA BY HUMAN-TUMOR AND SV40-TRANSFORMED HUMAN CELL STRAINS [J].

DAY, RS ;

ZIOLKOWSKI, CHJ ;

SCUDIERO, DA ;

MEYER, SA ;

LUBINIECKI, AS ;

GIRARDI, AJ ;

GALLOWAY, SM ;

BYNUM, GD .

NATURE, 1980, 288 (5792) :724-727

[10] CORRELATION BETWEEN O-6-METHYLGUANINE-DNA-METHYLTRANSFERASE ACTIVITY AND RESISTANCE OF HUMAN-CELLS TO THE CYTO-TOXIC AND MUTAGENIC EFFECT OF N-METHYL-N'-NITRO-N-NITROSOGUANIDINE [J].

DOMORADZKI, J ;

PEGG, AE ;

DOLAN, ME ;

MAHER, VM ;

MCCORMICK, JJ .

CARCINOGENESIS, 1984, 5 (12) :1641-1647

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