ACTIVATED LYMPHOCYTE-T SUBSETS IN EXPERIMENTAL ALLERGIC NEURITIS

被引：6

作者：

HAMAGUCHI, K ^{[1
]}

OHNO, R ^{[1
]}

TSUJI, T ^{[1
]}

YAMASHITA, T ^{[1
]}

NEGISHI, T ^{[1
]}

NOMURA, K ^{[1
]}

HOSOKAWA, T ^{[1
]}

机构：

[1] SAITAMA MED SCH,DEPT NEUROL,38 MOROYAMA,MOROYAMA,SAITAMA 35004,JAPAN

来源：

JOURNAL OF NEUROIMMUNOLOGY | 1991年 / 34卷 / 2-3期

关键词：

EXPERIMENTAL ALLERGIC NEURITIS; 2-COLOR IMMUNOFLUORESCENCE FLOW CYTOMETRY; ACTIVATED CD4+ T-CELL; ACTIVATED CD8+ T-CELL;

D O I：

10.1016/0165-5728(91)90129-U

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Changes in activated T cell subsets in peripheral blood were examined during the course of experimental allergic neuritis (EAN), using two-color immunofluorescence flow cytometry. Both CD4+ and CD8+ activated T cells decreased transiently before the onset of clinical signs, and increased just around the time of onset of the disease. In contrast, during the recovery phase, the numbers of CD4+ activated T cells returned to the normal range, whereas CD8+ activated T cells continued to increase. These findings imply that activation of CD4+ helper/inducer cells contributes mainly to the evolution of EAN, and that of CD8+ suppressor cells are necessary for recovery.

引用

页码：191 / 196

页数：6

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