SYNERGISTIC BACTERICIDAL ACTIVITY OF RAT SERUM WITH VANCOMYCIN AGAINST ENTEROCOCCI

被引：15

作者：

GOLD, MJ ^{[1
]}

CALMON, J ^{[1
]}

WENDELER, M ^{[1
]}

LEVISON, ME ^{[1
]}

JOHNSON, CC ^{[1
]}

机构：

[1] DEPT VET AFFAIRS,DIV INFECT DIS,PHILADELPHIA,PA

来源：

JOURNAL OF INFECTIOUS DISEASES | 1991年 / 163卷 / 06期

关键词：

D O I：

10.1093/infdis/163.6.1358

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Animal models of infectious diseases may not predict clinical efficacy when species-related factors come into play. Recently, unexpected bactericidal activity of vancomycin alone against enterococci was observed in a rat model of endocarditis. A factor or factors in rat serum, but not rabbit or human serum, enhanced in vitro killing by vancomycin in four of five clinical isolates of enterococci. Bactericidal activity was maintained on dilution of rat serum to 5.0% and after exposure of serum to 56-degrees-C for 30 min. Activity was lost by heating at 60-degrees-C for 2 h, ultrafiltration, or absorption with bentonite or heat-killed bacteria. Rat serum appears to contain a factor or factors that contribute bactericidal activity to vancomycin, a drug normally bacteriostatic for these enterococci. The mechanism by which this factor enhances killing of enterococci by vancomycin is unknown.

引用

页码：1358 / 1361

页数：4

共 15 条

[1]

BADDOUR LM, 1989, REV INFECT DIS, V3, P452

[2] HIGH-LEVEL PENICILLIN RESISTANCE AMONG ISOLATES OF ENTEROCOCCI - IMPLICATIONS FOR TREATMENT OF ENTEROCOCCAL INFECTIONS [J].