INHIBITION OF HERPESVIRUS PLAQUING CAPACITY IN HUMAN-DIPLOID FIBROBLASTS TREATED WITH GILVOCARCIN-V PLUS NEAR UV-RADIATION

被引：8

作者：

BOCKSTAHLER, LE ^{[1
]}

ELESPURU, RK ^{[1
]}

HITCHINS, VM ^{[1
]}

CARNEY, PG ^{[1
]}

OLVEY, KM ^{[1
]}

LYTLE, CD ^{[1
]}

机构：

[1] NCI,FREDERICK CANC RES FACIL,BASIC RES PROGRAM,CHEM & PHYS CARCINOGENESIS LAB,FREDERICK,MD 21701

来源：

PHOTOCHEMISTRY AND PHOTOBIOLOGY | 1990年 / 51卷 / 04期

关键词：

D O I：

10.1111/j.1751-1097.1990.tb01740.x

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Abstract— The capacity of human fibroblasts to support plaque formation by Herpes simplex virus following treatment of the cells with gilvocarcin V, a polyaromatic C‐glycoside. plus near ultraviolet radiation (UVA,320–400 nm) was examined. Gilvocarcin V, plus UVA radiation, effectively inhibited host cell capacity at concentrations five orders of magnitude lower than that of 8‐methyoxypsoralen required for capacity inhibition at similar levels of UVA radiation. This result extends the observation of unusual biological potency of UVA‐activafed gilvocarcins from bacterial cells to human cells. Copyright © 1990, Wiley Blackwell. All rights reserved

引用

页码：477 / 479

页数：3

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