THE EFFECT OF INOSITOL ON LITHIUM-INDUCED POLYURIA POLYDIPSIA IN RATS AND HUMANS

被引：18

作者：

BERSUDSKY, Y ^{[1
]}

VINNITSKY, I ^{[1
]}

GRISARU, N ^{[1
]}

YAROSLAVSKY, U ^{[1
]}

GHEORGHIU, S ^{[1
]}

IVGI, D ^{[1
]}

KOFMAN, O ^{[1
]}

BELMAKER, RH ^{[1
]}

机构：

[1] BEN GURION UNIV NEGEV,DEPT BEHAV SCI,IL-84105 BEER SHEVA,ISRAEL

来源：

HUMAN PSYCHOPHARMACOLOGY-CLINICAL AND EXPERIMENTAL | 1992年 / 7卷 / 06期

关键词：

LITHIUM; INOSITOL; SIDE-EFFECTS; AFFECTIVE DISORDERS; POLYURIA; POLYDIPSIA;

D O I：

10.1002/hup.470070606

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

It has been proposed that lithium acts by inhibiting inositol monophosphatase, thereby lowering tissue inositol levels. We therefore studied inositol effects on a prominent lithium side-effect, polyuria-polydipsia, in rats and in humans. Rats were treated with daily injections i.p. LiCl for 14 days and were given 2.5 per cent inositol, 2.5 per cent mannitol or no additive in their drinking water. Fourteen patients complaining of lithium side-effects were recruited for the study after approval by the Helsinki Committee. Patients were treated with inositol in 500 mg capsules, two capsules three times daily for 5 days. In both experiments inositol ameliorated Li-induced polyuria-polydipsia. However, mannitol had similar but less powerful and perhaps less lasting effects in rats.

引用

页码：403 / 407

页数：5

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