HUMAN PAPILLOMAVIRUS TYPE-6A DNA IN THE LUNG-CARCINOMA OF A PATIENT WITH RECURRENT LARYNGEAL PAPILLOMATOSIS IS CHARACTERIZED BY A PARTIAL DUPLICATION

被引：66

作者：

DILORENZO, TP

TAMSEN, A

ABRAMSON, AL

STEINBERG, BM

机构：

[1] LONG ISL JEWISH MED CTR,DEPT OTOLARYNGOL & COMMUNICAT DISORDERS,NEW HYDE PK,NY 11042

[2] SUNY SYRACUSE,HLTH SCI CTR,SYRACUSE,NY 13210

来源：

JOURNAL OF GENERAL VIROLOGY | 1992年 / 73卷

关键词：

D O I：

10.1099/0022-1317-73-2-423

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

Transcriptionally active human papillomavirus type 6a (HPV-6a) DNA was detected in a lung carcinoma of a patient with recurrent laryngeal papillomatosis. The carcinoma contained episomal HPV-6a genomes that had a duplication of the upstream regulatory region, the late region and a portion of the early region. HPV-6a genomes found in benign laryngeal papillomas from the same patient did not contain this duplication. A role for the mutant molecules in the pathogenesis of the malignancy is suggested.

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页码：423 / 428

页数：6

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