OUABAIN - A LOCAL, PARACRINE, ALDOSTERONE SYNTHESIS REGULATING HORMONE

被引：16

作者：

SZALAY, KS

机构：

[1] Institute of Experimental Medicine, Hungarian Academy of Sciences, Budapest

来源：

LIFE SCIENCES | 1993年 / 52卷 / 22期

基金：

匈牙利科学研究基金会;

关键词：

D O I：

10.1016/0024-3205(93)90466-G

中图分类号：

R-3 [医学研究方法]; R3 [基础医学];

学科分类号：

1001 ;

摘要：

10(-4) M ouabain increases aldosterone production at 3.6 and 5.4 mM potassium concentrations, whereas at high potassium concentration (7 mM) even lower concentration of ouabain (10(-8) M) decreases it. As ouabain has been shown to be produced by the adrenal cortex, a local paracrine regulation of aldosterone production by ouabain is suggested depending on extracellular potassium concentration.

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页码：1777 / 1780

页数：4

相关论文

共 11 条

[1] EFFECTS OF OUABAIN ON STEROID PRODUCTION BY RAT ADRENAL-CELLS STIMULATED BY ANGIOTENSIN-II, ALPHA-1-24 ADRENOCORTICOTROPIN, AND POTASSIUM [J].

BRALEY, LM ;

WILLIAMS, GH ;

MENACHERY, A .

ENDOCRINOLOGY, 1978, 103 (06) :1997-2005

[2] ARTERIELLE KONZENTRATION, ARTERIO-VENOSE DIFFERENZ IM CORONARBLUT UND ORGANVERTEILUNG VON C14-MARKIERTEM LANATOSID C NACH RASCHER INTRAVENOSER INJEKTION [J].

BRETSCHNEIDER, HJ ;

SCHELER, F ;

SCHULZE, G ;

HABERLAND, G ;

EGER, W ;

MERCKER, H ;

DOERING, P ;

KOCHSIEK, K .

NAUNYN-SCHMIEDEBERGS ARCHIV FUR EXPERIMENTELLE PATHOLOGIE UND PHARMAKOLOGIE, 1962, 244 (02) :117-+

[3] A MULTIPLE COMPARISON PROCEDURE FOR COMPARING SEVERAL TREATMENTS WITH A CONTROL [J].

DUNNETT, CW .

JOURNAL OF THE AMERICAN STATISTICAL ASSOCIATION, 1955, 50 (272) :1096-1121

[4] EFFECTS OF OUABAIN AND POTASSIUM ON PROTEIN-SYNTHESIS AND ANGIOTENSIN-STIMULATED ALDOSTERONE SYNTHESIS IN BOVINE ADRENAL GLOMERULOSA CELLS [J].

ELLIOTT, ME ;

HADJOKAS, NE ;

GOODFRIEND, TL .

ENDOCRINOLOGY, 1986, 118 (04) :1469-1475

[5]

GUILLEMIN R, 1959, J LAB CLIN MED, V53, P830

[6] IDENTIFICATION AND CHARACTERIZATION OF A OUABAIN-LIKE COMPOUND FROM HUMAN PLASMA [J].

HAMLYN, JM ;

BLAUSTEIN, MP ;

BOVA, S ;

DUCHARME, DW ;

HARRIS, DW ;

MANDEL, F ;

MATHEWS, WR ;

LUDENS, JH .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1991, 88 (14) :6259-6263

[7]

MULLER J, 1988, MONOGRAPHS ENDOCRINO, V29

[8] PYRIDINE-NUCLEOTIDE REDOX STATE PARALLELS PRODUCTION OF ALDOSTERONE IN POTASSIUM-STIMULATED ADRENAL GLOMERULOSA CELLS [J].

PRALONG, WF ;

HUNYADY, L ;

VARNAI, P ;

WOLLHEIM, CB ;

SPAT, A .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1992, 89 (01) :132-136

[9] ROLE OF CA2+ IN RESPONSE OF ADRENAL GLOMERULOSA CELLS TO ANGIOTENSIN-II, ACTH, K+, AND OUABAIN [J].

SCHIFFRIN, EL ;

LIS, M ;

GUTKOWSKA, J ;

GENEST, J .

AMERICAN JOURNAL OF PHYSIOLOGY, 1981, 241 (01) :E42-E46

[10]

SZALAY KS, 1981, ACTA PHYSIOL HUNG, V57, P225