BIOSYNTHETIC INCORPORATION OF NONNATURAL AMINO-ACIDS INTO PROTEINS

被引：13

作者：

BRUNNER, J

机构：

[1] Department of Biochemistry, ETH-Zentrum, CH-8092 Zürich, Switzerland

[2] HTL Burgdorf

[3] ETH Zürich

[4] ETH, Department of Biochemistry

来源：

CHEMICAL SOCIETY REVIEWS | 1993年 / 22卷 / 03期

关键词：

D O I：

10.1039/cs9932200183

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

This article summarizes recently developed methods of incorporating non-natural amino acids into proteins. These methods rely on the chemical aminoacylation of artificial [(semi)synthetic or in vitro transcribed] transfer RNAs that recognize a unique 'blank' codon in appropriately engineered messenger RNAs. By introducing 'designer' amino acids, it is possible to generate novel probes of protein structure and function.

引用

页码：183 / 189

页数：7

共 33 条

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