TREATMENT OF MULTIFOCAL MOTOR NEUROPATHY WITH HIGH-DOSE INTRAVENOUS IMMUNOGLOBULINS - A DOUBLE-BLIND, PLACEBO-CONTROLLED STUDY

被引：208

作者：

VANDENBERG, LH

KERKHOFF, H

OEY, PL

FRANSSEN, H

MOLLEE, I

VERMEULEN, M

JENNEKENS, FGI

WOKKE, JHJ

机构：

[1] UNIV UTRECHT HOSP, DEPT CLIN NEUROPHYSIOL, UTRECHT, NETHERLANDS

[2] UNIV HOSP AMSTERDAM, DEPT NEUROL, AMSTERDAM, NETHERLANDS

来源：

JOURNAL OF NEUROLOGY NEUROSURGERY AND PSYCHIATRY | 1995年 / 59卷 / 03期

关键词：

IMMUNOGLOBULINS; MULTIFOCAL MOTOR NEUROPATHY; DOUBLE BLIND PLACEBO CONTROLLED STUDY;

D O I：

10.1136/jnnp.59.3.248

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

The effect of high dose intravenous immunoglobulin (IVIg) treatment was studied in six patients with multifocal motor neuropathy (MMN). All patients responded to treatment (0.4 g/kg for five consecutive days) in an open trial. The effect of IVIg treatment was confirmed for each patient in a single patient, double blind, placebo controlled trial. Four patients received two IVIg treatments and two placebo treatments, and two patients received one IVIg and one placebo treatment in a randomised order. Five out of six patients responded to IVIg but not to placebo. One patient responded to IVIg in the same manner as to placebo treatment. Thus IVIg treatment can lead to improvement of muscle strength in patients with MMN.

引用

页码：248 / 252

页数：5

共 15 条

[1] INTRAVENOUS IMMUNOGLOBULIN TREATMENT IN PATIENTS WITH MOTOR-NEURON SYNDROMES ASSOCIATED WITH ANTI-GM1 ANTIBODIES - A DOUBLE-BLIND, PLACEBO-CONTROLLED STUDY [J].