PERMISSIVE EFFECT OF VIP ON THE HYPERGLYCEMIC RESPONSE INDUCED BY 2-DEOXY-D-GLUCOSE

被引：12

作者：

SHIMIZU, K ^{[1
]}

HIBINO, H ^{[1
]}

KOMENAMI, N ^{[1
]}

NAGAI, N ^{[1
]}

NAGAI, K ^{[1
]}

NAKAGAWA, H ^{[1
]}

机构：

[1] OSAKA UNIV,INST PROT RES,DIV PROT METAB,SUITA,OSAKA 565,JAPAN

来源：

NEUROSCIENCE LETTERS | 1994年 / 175卷 / 1-2期

关键词：

VASOACTIVE INTESTINAL PEPTIDE; HYPERGLUCAGONEMIA; GLUCOSE; ANTI-VIP ANTIBODY; RAT; BRAIN;

D O I：

10.1016/0304-3940(94)91103-7

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

We previously obtained evidence that in rats the neurons in the suprachiasmatic nucleus (SCN) receiving retinal neural inputs may be involved in the regulation of glucose metabolism. In this study we examined whether the SCN neurons containing vasoactive intestinal peptide (VIP)-like immunoreactive substance (VIP neurons) are involved in its regulation. We found that the hyperglycemic and hyperglucagonemic responses to intracranial injection of 2-deoxy-D-glucose (2DG) were synergistically enhanced by intracranial administration of VIP, and that these responses were significantly suppressed by treatment with anti-VIP antibody. These results suggest that VIP has a permissive effect on the hyperglycemic and hyperglucagonemic responses to 2DG, and thus that the VIP neurons in the SCN are probably involved in the regulation of glucose metabolism.

引用

页码：157 / 160

页数：4

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