A WEAK ASSOCIATION BETWEEN TH AND DRD2 GENES AND BIPOLAR AFFECTIVE-DISORDER IN A SPANISH SAMPLE

被引：41

作者：

PEREZ DE CASTRO, I

SANTOS, J

TORRES, P

VISEDO, G

SAIZRUIZ, J

LLINARES, C

FERNANDEZPIQUERAS, J

机构：

[1] UNIV SANTIAGO, FAC BIOL, DEPT BIOL FUNDAMENTAL, SANTIAGO, SPAIN

[2] HOSP RAMON Y CAJAL, SERV PSIQUIATRIA, MADRID, SPAIN

[3] UNIV ALCALA DE HENARES, MADRID, SPAIN

来源：

JOURNAL OF MEDICAL GENETICS | 1995年 / 32卷 / 02期

关键词：

D O I：

10.1136/jmg.32.2.131

中图分类号：

Q3 [遗传学];

学科分类号：

071007 ; 090102 ;

摘要：

Genetic factors play an important role in the aetiology of bipolar affective disorder (BP). So far, results of Linkage studies have been largely disappointing. We have searched for a possible association between polymorphic DNA markers of two candidate genes (tyrosine hydroxylase, TH; dopamine D2 receptor gene, DRD2) and BP in a population from central Spain. Our results are consistent with the existence of a weak association between these two genes and BP, in such a way that TH and DRD2 could be considered as minor genes contributing to susceptibility.

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页码：131 / 134

页数：4

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