SYNTHESIS AND BIOACTIVITY OF LINCOMYCIN-7-MONOESTERS

被引：12

作者：

SINKULA, AA

MOROZOWI.W

LEWIS, C

MACKELLA.FA

机构：

[1] Research Laboratories, Up-John Company, Kalamazoo, Michigan

来源：

JOURNAL OF PHARMACEUTICAL SCIENCES | 1969年 / 58卷 / 11期

关键词：

Bioactivity; in oiuo; in oitro—lincomycin‐7‐monoesters; GLC—analysis; Lincomycin‐7‐monoesters‐synthesis; NMR spectroscopy—structure; TLC—separation; identification;

D O I：

10.1002/jps.2600581121

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

A series of linear acyl and alkoxy esters at Position 7 in the lincomycin molecule were synthesized. None of the esters possessed protective properties comparable to those of lincomycin when given orally to experimentally infected mice. Copyright © 1969 Wiley‐Liss, Inc., A Wiley Company

引用

页码：1389 / &

共 9 条

[1]

HANKA LJ, 1962, ANTIMICROBIAL AGENTS, P565

[2]

Herr R. R., 1962, ANTIMICROB AGENTS CH, P560

[3]

HOUTMAN RL, Patent No. 3418414

[4]

LEWIS C, 1962, ANTIMICROBIAL AGENTS, P570

[5]

Mason DJ., 1962, ANTIMICROBIAL AGENTS, P554

[6]

MOROZOWICH W, IN PRESS

[7] LINCOMYCIN .4. NUCLEAR MAGNETIC RESONANCE STUDIES ON STRUCTURE OF LINCOMYCIN ITS DEGRADATION PRODUCTS AND SOME ANALOGS [J].

SLOMP, G ;

MACKELLAR, FA .

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 1967, 89 (10) :2454-+

[8]

SPEARMAN C, 1964, STATISTICAL METHOD B, P524

[9]

TARASZKA MJ, TO BE PUBLISHED

← 1 →