SYNTHESIS OF HIGHLY DIVERSIFIED CARRIER AMPHOLYTES - EVALUATION OF THE RESOLVING POWER OF ISOELECTRIC-FOCUSING IN THE PI SYSTEM (ALPHA-1-ANTITRYPSIN GENETIC-POLYMORPHISM)

The use of condensing reagents such as epoxypropanol, diepoxyoctane, acrylamide nad N,N′-methylenebisacrylamide in the synthesis of carrier ampholytes increased the diversity of amphoteric components. The quality of these synthetic carrier ampholytes has been tested in the separation of variants of alpha-1 antitrypsin a genetic polymorphism called the Pi system. A resolving power of the order of 0.005 pH unit was obtained. © 1979.