STRUCTURE OF GERM LINE IMMUNOGLOBULIN-ALPHA HEAVY-CHAIN RNA AND ITS LOCATION ON POLYSOMES

被引：61

作者：

RADCLIFFE, G

LIN, YC

JULIUS, M

MARCU, KB

STAVNEZER, J

机构：

[1] UNIV MASSACHUSETTS,SCH MED,DEPT MOLEC GENET & MICROBIOL,WORCESTER,MA 01605

[2] SUNY STONY BROOK,DEPT BIOCHEM,STONY BROOK,NY 11733

来源：

MOLECULAR AND CELLULAR BIOLOGY | 1990年 / 10卷 / 01期

关键词：

D O I：

10.1128/MCB.10.1.382

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

We describe the structure of the major germ line RNA transcribed from unrearranged immunoglobulin α heavy-chain genes in immunoglobulin M-expressing cells of the I.29μ B-cell lymphoma, a cell line capable of switching to immunoglobulin A expression upon lipopolysaccharide treatment. This germ line α RNA has a small open reading frame that does not include the Cα domain, and this RNA appears to be present on polysomes in I.29μ cells.

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页码：382 / 386

页数：5

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